{"id":"dioxadrol","rwe":[{"pmid":"20451396","year":"2010","title":"Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.","finding":"","journal":"Bioorganic & medicinal chemistry","studyType":"Clinical Study"},{"pmid":"7821343","year":"1994","title":"Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"22291389","year":"1992","title":"Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists.","finding":"","journal":"Journal of psychopharmacology (Oxford, England)","studyType":"Clinical Study"},{"pmid":"2203900","year":"1990","title":"Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"1980428","year":"1990","title":"Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.","finding":"","journal":"Canadian journal of physiology and pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"dioxadrol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["dioxadrol"],"offLabel":[],"synonyms":["dioxadrol"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Sigma non-opioid intracellular receptor 1","modality":"Small Molecule","drugClass":"dioxadrol","explanation":"Imagine your body's cells have locks on them, and DIOXADROL is a key that fits into one of those locks. When it binds, it can affect how the cell works, but without knowing the target, it's hard to say exactly how. This is a simplified explanation, and the actual mechanism is likely much more complex.","oneSentence":"DIOXADROL is a small molecule that works by interacting with a specific target, although the exact target and mechanism are unknown.","technicalDetail":"DIOXADROL's exact mechanism of action is unknown, but it is classified under the dioxadrol class, suggesting it may interact with a specific receptor or enzyme."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3158","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIOXADROL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:40:44.422713","biosimilars":[],"competitors":[{"drugName":"dextromethorphan","drugSlug":"dextromethorphan","fdaApproval":"1957-12-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dolutegravir","drugSlug":"dolutegravir","fdaApproval":"2013-08-12","patentExpiry":"Oct 5, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"donepezil","drugSlug":"donepezil","fdaApproval":"1996-11-25","patentExpiry":"Sep 23, 2037","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"fentanyl","drugSlug":"fentanyl","fdaApproval":"1968-02-19","patentExpiry":"Jan 25, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"haloperidol","drugSlug":"haloperidol","fdaApproval":"1967-04-12","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"pentazocine","drugSlug":"pentazocine","fdaApproval":"1967-07-24","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"progesterone","drugSlug":"progesterone","fdaApproval":"1976-02-04","patentExpiry":"Jan 21, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"sufentanil","drugSlug":"sufentanil","fdaApproval":"1984-05-04","patentExpiry":"Oct 22, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"tranylcypromine","drugSlug":"tranylcypromine","fdaApproval":"1961-02-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"dioxadrol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dextromethorphan","brandName":"dextromethorphan","genericName":"dextromethorphan","approvalYear":"1957","relationship":"same-target"},{"drugId":"dolutegravir","brandName":"dolutegravir","genericName":"dolutegravir","approvalYear":"2013","relationship":"same-target"},{"drugId":"donepezil","brandName":"donepezil","genericName":"donepezil","approvalYear":"1996","relationship":"same-target"},{"drugId":"fentanyl","brandName":"fentanyl","genericName":"fentanyl","approvalYear":"1968","relationship":"same-target"},{"drugId":"haloperidol","brandName":"haloperidol","genericName":"haloperidol","approvalYear":"1967","relationship":"same-target"},{"drugId":"pentazocine","brandName":"pentazocine","genericName":"pentazocine","approvalYear":"1967","relationship":"same-target"},{"drugId":"progesterone","brandName":"progesterone","genericName":"progesterone","approvalYear":"1976","relationship":"same-target"},{"drugId":"sufentanil","brandName":"sufentanil","genericName":"sufentanil","approvalYear":"1984","relationship":"same-target"},{"drugId":"tranylcypromine","brandName":"tranylcypromine","genericName":"tranylcypromine","approvalYear":"1961","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"4D70V7R51N","INN_ID":"1505","UMLSCUI":"C0114219","ChEMBL_ID":"CHEMBL1165411","PUBCHEM_CID":"66270","MESH_SUPPLEMENTAL_RECORD_UI":"C005840"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2010 Jun 1","pmid":"20451396","title":"Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.","journal":"Bioorganic & medicinal chemistry"},{"date":"1994 Sep 22","pmid":"7821343","title":"Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors.","journal":"European journal of pharmacology"},{"date":"1992 Jan","pmid":"22291389","title":"Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists.","journal":"Journal of psychopharmacology (Oxford, England)"},{"date":"1990 Sep","pmid":"2203900","title":"Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1990 Sep","pmid":"1980428","title":"Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.","journal":"Canadian journal of physiology and pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"DIOXADROL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dioxadrol is a small molecule with the synonyms CL-639C, DIOXADROL HCL, DIOXADROL HYDROCHLORIDE, DIOXADROL HYDROCHLORIDE, NSC-70774, and RYDAR. However, no specific information is available on its clinical indications or mechanism of action.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}