{"id":"diodone","rwe":[{"pmid":"26819427","year":"2016","title":"[Evaluation of risk factors and prognosis on diodone-induced acute kidney injury according to ESUR and KDIGO criteria].","finding":"","journal":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences","studyType":"Clinical Study"},{"pmid":"3559449","year":"1987","title":"Inhibitory effect of various radiographic contrast agents on secretion of thyroxine by the dog thyroid and on peripheral and thyroidal deiodination of thyroxine to tri-iodothyronine.","finding":"","journal":"The Journal of endocrinology","studyType":"Clinical Study"},{"pmid":"6548397","year":"1984","title":"Does a water soluble contrast enema assist in the management of acute large bowel obstruction: a prospective study of 117 cases.","finding":"","journal":"The British journal of surgery","studyType":"Clinical Study"},{"pmid":"319817","year":"1977","title":"Arterial pressure studies during carotid angiography.","finding":"","journal":"British journal of anaesthesia","studyType":"Clinical Study"},{"pmid":"5382727","year":"1969","title":"[Diagnostic value of hysterosalpingography performed with diodone in sterility].","finding":"","journal":"Sovetskaia meditsina","studyType":"Clinical Study"}],"tags":[{"label":"diodone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AA10","category":"atc"},{"label":"Active","category":"status"},{"label":"Contrast Media","category":"pharmacology"},{"label":"Diagnostic Uses of Chemicals","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diodon","offLabel":[],"synonyms":["diodone","diodon","iodopyracet"],"timeline":[],"approvals":[],"brandName":"Diodon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"diodone","explanation":"Think of prostaglandins like messengers that tell your body to feel pain and become inflamed. When Diodon blocks these messengers, it helps to reduce pain and inflammation. This can be especially helpful for people with conditions like arthritis or other inflammatory diseases.","oneSentence":"Diodon works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","technicalDetail":"Diodon is a COX inhibitor, which means it blocks the action of the cyclooxygenase enzyme (COX-1 and/or COX-2) that converts arachidonic acid into prostaglandins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4449","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIODONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:40:39.574064","biosimilars":[],"competitors":[{"drugName":"diatrizoate","drugSlug":"diatrizoate","fdaApproval":"1954-11-26","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metrizoic acid","drugSlug":"metrizoic-acid","fdaApproval":"1973-11-17","relationship":"same-class"},{"drugName":"iodamide","drugSlug":"iodamide","fdaApproval":"1978-07-25","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iotalamic acid","drugSlug":"iotalamic-acid","fdaApproval":"1963-09-30","relationship":"same-class"},{"drugName":"acetrizoic acid","drugSlug":"acetrizoic-acid","fdaApproval":"","relationship":"same-class"}],"genericName":"diodone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diatrizoate","brandName":"diatrizoate","genericName":"diatrizoate","approvalYear":"1954","relationship":"same-class"},{"drugId":"metrizoic-acid","brandName":"metrizoic acid","genericName":"metrizoic acid","approvalYear":"1973","relationship":"same-class"},{"drugId":"iodamide","brandName":"iodamide","genericName":"iodamide","approvalYear":"1978","relationship":"same-class"},{"drugId":"iotalamic-acid","brandName":"iotalamic acid","genericName":"iotalamic acid","approvalYear":"1963","relationship":"same-class"},{"drugId":"acetrizoic-acid","brandName":"acetrizoic acid","genericName":"acetrizoic acid","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002346","UNII":"ZTK4026YJ5","INN_ID":"1763","UMLSCUI":"C0021990","ChEMBL_ID":"CHEMBL2105036","DRUGBANK_ID":"DB13568","PUBCHEM_CID":"5284574","MESH_DESCRIPTOR_UI":"D007468"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":38,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"V08AA10","allCodes":["V08AA10"]},"biosimilarFilings":[],"recentPublications":[{"date":"2016 Jan","pmid":"26819427","title":"[Evaluation of risk factors and prognosis on diodone-induced acute kidney injury according to ESUR and KDIGO criteria].","journal":"Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences"},{"date":"1987 Mar","pmid":"3559449","title":"Inhibitory effect of various radiographic contrast agents on secretion of thyroxine by the dog thyroid and on peripheral and thyroidal deiodination of thyroxine to tri-iodothyronine.","journal":"The Journal of endocrinology"},{"date":"1984 Oct","pmid":"6548397","title":"Does a water soluble contrast enema assist in the management of acute large bowel obstruction: a prospective study of 117 cases.","journal":"The British journal of surgery"},{"date":"1977 Feb","pmid":"319817","title":"Arterial pressure studies during carotid angiography.","journal":"British journal of anaesthesia"},{"date":"1969 Oct","pmid":"5382727","title":"[Diagnostic value of hysterosalpingography performed with diodone in sterility].","journal":"Sovetskaia meditsina"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diodon (DIODONE) is a small molecule drug in the diodone class, but specific details about its target, FDA approval status, and approved indications are unknown. As a diodone, it is likely a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which plays a key role in the production of prostaglandins that cause pain and inflammation. The commercial status of Diodon is also unclear, with no information available on whether it is patented or generic. Further research is needed to determine the safety considerations and potential side effects of Diodon. Overall, Diodon appears to be a relatively unknown drug with limited information available.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}