{"id":"dinoprost","rwe":[{"pmid":"41788845","year":"2026","title":"Administering the maternal bovine appeasing substance improves fertility in lactating dairy cows.","finding":"","journal":"JDS communications","studyType":"Clinical Study"},{"pmid":"41747008","year":"2026","title":"Absolute Quantification of Full-Length 16S rRNA Amplicon Sequencing and Metabolomic Profiling of Red-Stipe Disease in Morel Fruiting Bodies.","finding":"","journal":"Phytopathology","studyType":"Clinical Study"},{"pmid":"41698585","year":"2026","title":"Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows.","finding":"","journal":"Journal of dairy science","studyType":"Clinical Study"},{"pmid":"40972794","year":"2026","title":"Revealing and validating the biomarkers associated with demethylation in major depressive disorder: comprehensive insights based on bulk RNA 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benign","category":"indication"},{"label":"Incomplete miscarriage","category":"indication"},{"label":"Induction of labor","category":"indication"},{"label":"Pregnancy with abortive outcome","category":"indication"},{"label":"Pfizer","category":"company"},{"label":"Approved 1970s","category":"decade"},{"label":"Abortifacient Agents","category":"pharmacology"},{"label":"Abortifacient Agents, Nonsteroidal","category":"pharmacology"},{"label":"Oxytocics","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[{"effect":"Any fetal heart rate abnormality","drugRate":"17%","severity":"common","organSystem":""},{"effect":"Uterine contractile abnormality","drugRate":"6.6%","severity":"common","organSystem":""},{"effect":"Any gastrointestinal effect","drugRate":"5.7%","severity":"common","organSystem":""},{"effect":"Bradycardia","drugRate":"4.1%","severity":"common","organSystem":""},{"effect":"Variable 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of cervix","Kidney disease","Low blood pressure","Multiple pregnancy","Ocular hypertension","Placenta previa"],"seriousAdverseEvents":[{"effect":"Uterine rupture","drugRate":"","severity":"serious"},{"effect":"Amnionitis","drugRate":"","severity":"serious"},{"effect":"Intrauterine fetal sepsis","drugRate":"","severity":"serious"},{"effect":"Premature rupture of membranes","drugRate":"","severity":"serious"},{"effect":"Fetal depression (1 min Apgar < 7)","drugRate":"","severity":"serious"},{"effect":"Fetal acidosis (umbilical artery pH < 7.15)","drugRate":"","severity":"serious"},{"effect":"Post-partum disseminated intravascular coagulation","drugRate":"0.1%","severity":"serious"},{"effect":"Anaphylactic reaction","drugRate":"","severity":"serious"},{"effect":"Anaphylactic shock","drugRate":"","severity":"serious"},{"effect":"Anaphylactoid 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agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:35:32.768254+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200896/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:35:32.665296+00:00"}},"allNames":"enzaprost","offLabel":[],"synonyms":["dinoprost","enzaprost","Prostaglandin F2","dinoprost tromethamine","dinoprost trometamol"],"timeline":[{"date":"1976-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from PHARMACIA AND UPJOHN to Pfizer"},{"date":"1976-05-18","type":"positive","source":"DrugCentral","milestone":"FDA approval (Pharmacia And Upjohn)"},{"date":"1992-12-09","type":"positive","source":"FDA Orange Book","milestone":"Prepidil approved — 0.5MG/3GM"},{"date":"1995-03-30","type":"positive","source":"FDA Orange Book","milestone":"Cervidil approved — 10MG"}],"aiSummary":"Enzaprost (DINOPROST) is a small molecule drug developed by PHARMACIA AND UPJOHN and currently owned by Pfizer. It targets the prostaglandin F2-alpha receptor and is classified as a dinoprost. Enzaprost is FDA-approved for various indications, including cervical ripening, hydatidiform mole, incomplete miscarriage, induction of labor, and pregnancy with abortive outcome. It is off-patent and has no active Orange Book patents, indicating that it is available as a generic medication. As a result, there are currently no generic manufacturers of Enzaprost.","approvals":[{"date":"1976-05-18","orphan":false,"company":"PHARMACIA AND UPJOHN","regulator":"FDA"}],"brandName":"Enzaprost","ecosystem":[{"indication":"Cervical ripening procedure","otherDrugs":[{"name":"dinoprostone","slug":"dinoprostone","company":"Pharmacia And Upjohn"}],"globalPrevalence":null},{"indication":"Hydatidiform mole, benign","otherDrugs":[{"name":"dinoprostone","slug":"dinoprostone","company":"Pharmacia And Upjohn"}],"globalPrevalence":null},{"indication":"Incomplete miscarriage","otherDrugs":[{"name":"dinoprostone","slug":"dinoprostone","company":"Pharmacia And Upjohn"},{"name":"oxytocin","slug":"oxytocin","company":"Novartis"}],"globalPrevalence":null},{"indication":"Induction of labor","otherDrugs":[{"name":"dinoprostone","slug":"dinoprostone","company":"Pharmacia And Upjohn"},{"name":"oxytocin","slug":"oxytocin","company":"Novartis"}],"globalPrevalence":null},{"indication":"Pregnancy with abortive outcome","otherDrugs":[{"name":"carboprost","slug":"carboprost","company":"Pharmacia And Upjohn"},{"name":"dinoprostone","slug":"dinoprostone","company":"Pharmacia And Upjohn"},{"name":"mifepristone","slug":"mifepristone","company":"Danco Labs Llc"},{"name":"oxytocin","slug":"oxytocin","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"target":"Prostaglandin F2-alpha receptor","novelty":"Follow-on","targets":[{"gene":"PTGFR","source":"DrugCentral","target":"Prostaglandin F2-alpha receptor","protein":"Prostaglandin F2-alpha receptor"},{"gene":"PTGER3","source":"DrugCentral","target":"Prostaglandin E2 receptor EP3 subtype","protein":"Prostaglandin E2 receptor EP3 subtype"},{"gene":"PTGER1","source":"DrugCentral","target":"Prostaglandin E2 receptor EP1 subtype","protein":"Prostaglandin E2 receptor EP1 subtype"},{"gene":"PTGDR2","source":"DrugCentral","target":"Prostaglandin D2 receptor 2","protein":"Prostaglandin D2 receptor 2"},{"gene":"PTGER2","source":"DrugCentral","target":"Prostaglandin E2 receptor EP2 subtype","protein":"Prostaglandin E2 receptor EP2 subtype"},{"gene":"PTGER4","source":"DrugCentral","target":"Prostaglandin E2 receptor EP4 subtype","protein":"Prostaglandin E2 receptor EP4 subtype"},{"gene":"PTGDR","source":"DrugCentral","target":"Prostaglandin D2 receptor","protein":"Prostaglandin D2 receptor"},{"gene":"TBXA2R","source":"DrugCentral","target":"Thromboxane A2 receptor","protein":"Thromboxane A2 receptor"}],"modality":"Small Molecule","drugClass":"dinoprost","explanation":"","oneSentence":"","technicalDetail":"Enzaprost (dinoprost) is a prostaglandin F2-alpha receptor agonist that mimics the action of natural prostaglandins, such as PGF2α, to induce labor and cervical ripening by stimulating uterine contractions and cervical softening through a G-protein coupled receptor mechanism."},"commercial":{"launchDate":"1976","_launchSource":"DrugCentral (FDA 1976-05-18, PHARMACIA AND UPJOHN)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/912","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DINOPROST","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DINOPROST","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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