{"id":"dimetotiazine","rwe":[{"pmid":"9666486","year":"1998","title":"[Effect of KB-2796, a novel calcium channel blocker, on spreading depression in rat hippocampal slices].","finding":"","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","studyType":"Clinical Study"},{"pmid":"9414039","year":"1997","title":"Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells.","finding":"","journal":"Japanese journal of pharmacology","studyType":"Clinical Study"},{"pmid":"9507571","year":"1997","title":"Effects of KB-2796 on plasma extravasation following antidromic trigeminal stimulation in the rat.","finding":"","journal":"Research communications in molecular pathology and pharmacology","studyType":"Clinical Study"},{"pmid":"8564192","year":"1995","title":"Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats.","finding":"","journal":"British journal of pharmacology","studyType":"Clinical Study"},{"pmid":"7497237","year":"1995","title":"[Migraine in childhood and adolescence: a retrospective review of hospital cases].","finding":"","journal":"Revista de neurologia","studyType":"Clinical Study"}],"tags":[{"label":"dimetotiazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N02CX05","category":"atc"},{"label":"Active","category":"status"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Histamine H1 Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"fonazine","offLabel":[],"synonyms":["dimetotiazine mesilate","fonazine mesylate","fonazine","dimethiotazine","dimethothiazine","dimetotiazine"],"timeline":[],"approvals":[],"brandName":"Fonazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimetotiazine","explanation":"Imagine your body's cells are like locks, and Fonazine is a key that fits into one of those locks. When it binds to the lock, it can affect how the cell works, but we don't know exactly how it does that yet. More research is needed to understand how Fonazine works at a molecular level.","oneSentence":"Fonazine is thought to work by interacting with a specific target in the body, although the exact mechanism is not well understood.","technicalDetail":"Dimetotiazine is a small molecule that binds to a specific target, although the identity of that target is currently unknown. This binding event is thought to trigger a cascade of downstream effects, but the precise mechanism of action remains to be elucidated."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1235","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dimetotiazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:44:39.410148","biosimilars":[],"competitors":[{"drugName":"clonidine","drugSlug":"clonidine","fdaApproval":"1974-09-03","patentExpiry":"Sep 8, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"dimetotiazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clonidine","brandName":"clonidine","genericName":"clonidine","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003519","UNII":"B28V86NGNK","CHEBI":"CHEBI:135616","INN_ID":"2034","RXNORM":"50138","UMLSCUI":"C0118092","ChEMBL_ID":"CHEMBL346977","KEGG_DRUG":"D07854","DRUGBANK_ID":"DB08967","PUBCHEM_CID":"3089","SECONDARY_CAS_RN":"13115-40-7","MESH_SUPPLEMENTAL_RECORD_UI":"C100113"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N02CX05","allCodes":["N02CX05"]},"biosimilarFilings":[],"recentPublications":[{"date":"1998 May","pmid":"9666486","title":"[Effect of KB-2796, a novel calcium channel blocker, on spreading depression in rat hippocampal slices].","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica"},{"date":"1997 Oct","pmid":"9414039","title":"Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells.","journal":"Japanese journal of pharmacology"},{"date":"1997 Jul","pmid":"9507571","title":"Effects of KB-2796 on plasma extravasation following antidromic trigeminal stimulation in the rat.","journal":"Research communications in molecular pathology and pharmacology"},{"date":"1995 Aug","pmid":"8564192","title":"Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats.","journal":"British journal of pharmacology"},{"date":"1995 Jul-Aug","pmid":"7497237","title":"[Migraine in childhood and adolescence: a retrospective review of hospital cases].","journal":"Revista de neurologia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Fonazine, also known as dimetotiazine, is a small molecule drug of the dimetotiazine class. Its target and exact mechanism of action are unknown. It is not FDA-approved for any indications. The commercial status of Fonazine, including whether it is patented or generic, and whether it is off-patent, is also unknown. Further research is needed to determine its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}