{"id":"dimetofrine","rwe":[{"pmid":"9467688","year":"1998","title":"Midodrine. A review of its therapeutic use in the management of orthostatic hypotension.","finding":"","journal":"Drugs & aging","studyType":"Clinical Study"},{"pmid":"2480881","year":"1989","title":"Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders.","finding":"","journal":"Drugs","studyType":"Clinical Study"},{"pmid":"5132376","year":"1971","title":"[The use of dimetofrine in shock].","finding":"","journal":"Rassegna internazionale di clinica e terapia","studyType":"Clinical Study"}],"tags":[{"label":"dimetofrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01CA12","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"anassicol","offLabel":[],"synonyms":["dimetofrine","anassicol","dimethophrine","dimetrophine"],"timeline":[],"approvals":[],"brandName":"Anassicol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimetofrine","explanation":"Imagine your body's cells have locks on them, and Anassicol is a key that fits into one of those locks. When it binds, it can either unlock or block the normal functioning of the cell, but we don't know which yet. This interaction can potentially affect various cellular processes, but more research is needed to understand how it works.","oneSentence":"Anassicol works by interacting with a specific target, but its exact mechanism is currently unknown.","technicalDetail":"Anassicol's mechanism of action is currently unknown, but it is classified as a dimetofrine, which suggests it may interact with adrenergic receptors or other targets involved in sympathetic nervous system regulation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/909","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DIMETOFRINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMETOFRINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:39:56.721660","biosimilars":[],"competitors":[{"drugName":"isoprenaline","drugSlug":"isoprenaline","fdaApproval":"1956-03-09","relationship":"same-class"},{"drugName":"norepinephrine","drugSlug":"norepinephrine","fdaApproval":"1950-07-13","patentExpiry":"Mar 8, 2041","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dopamine","drugSlug":"dopamine","fdaApproval":"1974-02-25","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenylephrine","drugSlug":"phenylephrine","fdaApproval":"1952-01-21","patentExpiry":"Sep 26, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dobutamine","drugSlug":"dobutamine","fdaApproval":"1978-07-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metaraminol","drugSlug":"metaraminol","fdaApproval":"1954-09-29","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methoxamine","drugSlug":"methoxamine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"mephentermine","drugSlug":"mephentermine","fdaApproval":"1951-12-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"midodrine","drugSlug":"midodrine","fdaApproval":"1996-09-06","genericCount":14,"patentStatus":"Off-patent — generic 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available","relationship":"same-class"}],"genericName":"dimetofrine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isoprenaline","brandName":"isoprenaline","genericName":"isoprenaline","approvalYear":"1956","relationship":"same-class"},{"drugId":"norepinephrine","brandName":"norepinephrine","genericName":"norepinephrine","approvalYear":"1950","relationship":"same-class"},{"drugId":"dopamine","brandName":"dopamine","genericName":"dopamine","approvalYear":"1974","relationship":"same-class"},{"drugId":"phenylephrine","brandName":"phenylephrine","genericName":"phenylephrine","approvalYear":"1952","relationship":"same-class"},{"drugId":"dobutamine","brandName":"dobutamine","genericName":"dobutamine","approvalYear":"1978","relationship":"same-class"},{"drugId":"metaraminol","brandName":"metaraminol","genericName":"metaraminol","approvalYear":"1954","relationship":"same-class"},{"drugId":"methoxamine","brandName":"methoxamine","genericName":"methoxamine","approvalYear":"","relationship":"same-class"},{"drugId":"mephentermine","brandName":"mephentermine","genericName":"mephentermine","approvalYear":"1951","relationship":"same-class"},{"drugId":"midodrine","brandName":"midodrine","genericName":"midodrine","approvalYear":"1996","relationship":"same-class"},{"drugId":"fenoldopam","brandName":"fenoldopam","genericName":"fenoldopam","approvalYear":"1997","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00296777","phase":"PHASE4","title":"Treatment of Depression Following Multiple Brain Tests","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2004-12","conditions":["Major Depression","Dysthymia"],"enrollment":28,"completionDate":"2007-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"BOM1J10QQM","CHEBI":"CHEBI:134932","INN_ID":"3092","UMLSCUI":"C0058204","ChEMBL_ID":"CHEMBL2105040","KEGG_DRUG":"D07149","DRUGBANK_ID":"DB13494","PUBCHEM_CID":"31513","MESH_SUPPLEMENTAL_RECORD_UI":"C100197"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C01CA12","allCodes":["C01CA12"]},"biosimilarFilings":[],"recentPublications":[{"date":"1998 Jan","pmid":"9467688","title":"Midodrine. A review of its therapeutic use in the management of orthostatic hypotension.","journal":"Drugs & aging"},{"date":"1989 Nov","pmid":"2480881","title":"Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders.","journal":"Drugs"},{"date":"1971 Sep 30","pmid":"5132376","title":"[The use of dimetofrine in shock].","journal":"Rassegna internazionale di clinica e terapia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Anassicol is a small molecule with synonyms including Dimethophrine, Dimetofrine, and Dimetofrine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}