{"id":"dimetindene","rwe":[],"tags":[{"label":"dimetindene","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H1 receptor","category":"target"},{"label":"HRH1","category":"gene"},{"label":"CHRM2","category":"gene"},{"label":"CHRM3","category":"gene"},{"label":"D04AA13","category":"atc"},{"label":"Active","category":"status"},{"label":"Margitta Worm","category":"company"},{"label":"Anti-Allergic Agents","category":"pharmacology"},{"label":"Antipruritics","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Histamine H1 Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_1","safety":{"safetySignals":[{"llr":215.621,"date":"","count":79,"signal":"Polyneuropathy","source":"DrugCentral FAERS","actionTaken":"Reported 79 times (LLR=216)"},{"llr":129.515,"date":"","count":105,"signal":"COVID-19","source":"DrugCentral FAERS","actionTaken":"Reported 105 times (LLR=130)"},{"llr":67.796,"date":"","count":94,"signal":"General physical health deterioration","source":"DrugCentral FAERS","actionTaken":"Reported 94 times (LLR=68)"},{"llr":65.565,"date":"","count":11,"signal":"Drug ineffective","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=66)"},{"llr":55.89,"date":"","count":22,"signal":"Renal pain","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=56)"},{"llr":54.269,"date":"","count":143,"signal":"Pyrexia","source":"DrugCentral FAERS","actionTaken":"Reported 143 times (LLR=54)"},{"llr":48.893,"date":"","count":8,"signal":"Thyroid stimulating immunoglobulin increased","source":"DrugCentral FAERS","actionTaken":"Reported 8 times (LLR=49)"},{"llr":48.196,"date":"","count":53,"signal":"Leukopenia","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=48)"},{"llr":46.936,"date":"","count":32,"signal":"Blood lactate dehydrogenase increased","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=47)"},{"llr":42.316,"date":"","count":18,"signal":"Coronavirus infection","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=42)"},{"llr":41.478,"date":"","count":9,"signal":"Chronic hepatitis B","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=41)"},{"llr":40.613,"date":"","count":9,"signal":"Anti-thyroid antibody positive","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=41)"},{"llr":39.999,"date":"","count":8,"signal":"Glomerulonephritis chronic","source":"DrugCentral FAERS","actionTaken":"Reported 8 times (LLR=40)"},{"llr":36.068,"date":"","count":21,"signal":"Flank pain","source":"DrugCentral FAERS","actionTaken":"Reported 21 times (LLR=36)"},{"llr":33.441,"date":"","count":23,"signal":"Oral herpes","source":"DrugCentral FAERS","actionTaken":"Reported 23 times (LLR=33)"}],"commonSideEffects":[{"effect":"Polyneuropathy","drugRate":"LLR 216","severity":"common"},{"effect":"COVID-19","drugRate":"LLR 130","severity":"common"},{"effect":"General physical health deterioration","drugRate":"LLR 68","severity":"common"},{"effect":"Renal pain","drugRate":"LLR 56","severity":"common"},{"effect":"Pyrexia","drugRate":"LLR 54","severity":"common"},{"effect":"Thyroid stimulating immunoglobulin increased","drugRate":"LLR 49","severity":"common"},{"effect":"Leukopenia","drugRate":"LLR 48","severity":"common"},{"effect":"Blood lactate dehydrogenase increased","drugRate":"LLR 47","severity":"common"},{"effect":"Coronavirus infection","drugRate":"LLR 42","severity":"common"},{"effect":"Chronic hepatitis B","drugRate":"LLR 41","severity":"common"},{"effect":"Anti-thyroid antibody positive","drugRate":"LLR 41","severity":"common"},{"effect":"Glomerulonephritis chronic","drugRate":"LLR 40","severity":"common"},{"effect":"Flank pain","drugRate":"LLR 36","severity":"common"},{"effect":"Oral herpes","drugRate":"LLR 33","severity":"common"}]},"trials":[],"aliases":[],"company":"Margitta Worm","patents":[],"pricing":[],"allNames":"dimethindene","offLabel":[],"synonyms":["dimetindene maleate","dimethindene maleate","dimethindene","dimetindene"],"timeline":[],"approvals":[],"brandName":"Dimethindene","ecosystem":[],"mechanism":{"target":"Histamine H1 receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2","targets":[{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"CHRM5","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M5","protein":"Muscarinic acetylcholine receptor M5"}],"modality":"Small Molecule","drugClass":"dimetindene","explanation":"Imagine your body has a system to respond to threats, like an allergic reaction. Histamine is a chemical that helps trigger this response. Dimethindene blocks the receptors that histamine binds to, reducing the severity of the allergic reaction.","oneSentence":"Dimethindene works by blocking the histamine H1 receptor, which is involved in allergic reactions and other histamine-related processes.","technicalDetail":"Dimethindene acts as a competitive antagonist at the histamine H1 receptor, inhibiting the binding of histamine and subsequent downstream signaling pathways involved in allergic responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/903","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dimetindene","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dimetindene","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:44:34.651036","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"dimetindene","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07341776","phase":"PHASE4","title":"Steroid Use in Treatment of Allergic Reactions to Food","status":"RECRUITING","sponsor":"Johannes Trueck","startDate":"2026-01-26","conditions":["Anaphylactic Reaction","Anaphylaxis","Allergy in Children","IgE Mediated Food Allergy"],"enrollment":160,"completionDate":"2026-12"},{"nctId":"NCT01448057","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu","status":"COMPLETED","sponsor":"Novartis","startDate":"2013-07","conditions":["Upper Respiratory Tract Infection","Nasal Congestion","Rhinorrhea","Sneezing"],"enrollment":341,"completionDate":"2015-08"},{"nctId":"NCT01026961","phase":"PHASE1,PHASE2","title":"Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers","status":"WITHDRAWN","sponsor":"Novartis","startDate":"2010-09","conditions":["Heart Rate","Blood Pressure","Arrhythmias"],"enrollment":0,"completionDate":""},{"nctId":"NCT02094287","phase":"NA","title":"Placebo Effect in the Treatment of Atopic Dermatitis","status":"COMPLETED","sponsor":"Margitta Worm","startDate":"2010-09","conditions":["Atopic Dermatitis"],"enrollment":166,"completionDate":"2015-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"003407","UNII":"6LL60J9E0O","CHEBI":"CHEBI:31500","INN_ID":"1403","RXNORM":"258334","UMLSCUI":"C0012390","ChEMBL_ID":"CHEMBL22108","KEGG_DRUG":"D01343","DRUGBANK_ID":"DB08801","PUBCHEM_CID":"21855","SNOMEDCT_US":"26122009","IUPHAR_LIGAND_ID":"10101","SECONDARY_CAS_RN":"3614-69-5","MESH_DESCRIPTOR_UI":"D004115"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"Margitta Worm","relationship":"Current Owner"}],"pharmacokinetics":{"source":"DrugCentral","halfLife":"4.6 hours","clearance":"4.83 mL/min/kg","volumeOfDistribution":"2.16 L/kg"},"publicationCount":72,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA13","allCodes":["D04AA13","R06AB03"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Margitta Worm","companyId":"margitta-worm","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dimethindene, also known as dimetindene, is a small molecule drug that targets the histamine H1 receptor. It is developed and owned by Margitta Worm, but its commercial status is unknown. Dimethindene is used to treat histamine-related conditions, although its approved indications are not specified. The drug has a half-life of 4.6 hours, but its bioavailability and generic manufacturing status are unknown. As a result, its availability and pricing are uncertain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}