{"id":"dimethylphthalate","rwe":[{"pmid":"37683795","year":"2023","title":"Endocrine disrupting chemicals in wastewater treatment plants in Kenya, East Africa: Concentrations, removal efficiency, mass loading rates and ecological impacts.","finding":"","journal":"Environmental research","studyType":"Clinical Study"},{"pmid":"37544523","year":"2023","title":"Concentrations of bisphenols and phthalate esters in the muscle of Mediterranean striped dolphins (Stenella coeruleoalba).","finding":"","journal":"Chemosphere","studyType":"Clinical Study"},{"pmid":"36675946","year":"2023","title":"Exploring Potent Fungal Isolates from Sanitary Landfill Soil for In Vitro Degradation of Dibutyl Phthalate.","finding":"","journal":"Journal of fungi (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"34537431","year":"2022","title":"Method development using chemometric tools for determination of endocrine-disrupting chemicals in bottled mineral waters.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"34047317","year":"2021","title":"An automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics.","finding":"","journal":"The Analyst","studyType":"Clinical Study"}],"tags":[{"label":"dimethylphthalate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P03BX02","category":"atc"},{"label":"Active","category":"status"},{"label":"Fixatives","category":"pharmacology"},{"label":"Insect Repellents","category":"pharmacology"},{"label":"Pesticides","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dimethyl phthalate","offLabel":[],"synonyms":["dimethylphthalate","dimethyl phthalate"],"timeline":[],"approvals":[],"brandName":"Dimethyl Phthalate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimethylphthalate","explanation":"In simple terms, dimethyl phthalate is thought to bind to specific proteins or receptors in the body, which triggers a series of chemical reactions that ultimately lead to its therapeutic effect. This binding process is highly specific and allows dimethyl phthalate to target specific cells or tissues without affecting others. The exact mechanism of action is not well understood and requires further research.","oneSentence":"Dimethyl phthalate works by interacting with cellular targets to produce a therapeutic effect.","technicalDetail":"Dimethyl phthalate is a small molecule that binds to specific targets, such as enzymes or receptors, to produce its therapeutic effect. This binding process is reversible and can be influenced by various factors, including the concentration of dimethyl phthalate and the presence of other molecules. The exact binding site and mechanism of action of dimethyl phthalate are unknown and require further investigation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4771","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dimethylphthalate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dimethylphthalate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:39:44.522699","biosimilars":[],"competitors":[{"drugName":"diethyltoluamide","drugSlug":"diethyltoluamide","fdaApproval":"","relationship":"same-class"}],"genericName":"dimethylphthalate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diethyltoluamide","brandName":"diethyltoluamide","genericName":"diethyltoluamide","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05997784","phase":"","title":"Study of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2025-01-30","conditions":["Asthma in Children","Allergy"],"enrollment":500,"completionDate":"2028-09-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"NOCODE","NDDF":"006241","UNII":"08X7F5UDJM","CHEBI":"CHEBI:4609","UMLSCUI":"C0058224","ChEMBL_ID":"CHEMBL323348","DRUGBANK_ID":"DB13336","PUBCHEM_CID":"8554","SNOMEDCT_US":"256094001","MESH_SUPPLEMENTAL_RECORD_UI":"C024629"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":69,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"P03BX02","allCodes":["P03BX02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Nov 15","pmid":"37683795","title":"Endocrine disrupting chemicals in wastewater treatment plants in Kenya, East Africa: Concentrations, removal efficiency, mass loading rates and ecological impacts.","journal":"Environmental research"},{"date":"2023 Oct","pmid":"37544523","title":"Concentrations of bisphenols and phthalate esters in the muscle of Mediterranean striped dolphins (Stenella coeruleoalba).","journal":"Chemosphere"},{"date":"2023 Jan 16","pmid":"36675946","title":"Exploring Potent Fungal Isolates from Sanitary Landfill Soil for In Vitro Degradation of Dibutyl Phthalate.","journal":"Journal of fungi (Basel, Switzerland)"},{"date":"2022 Feb 15","pmid":"34537431","title":"Method development using chemometric tools for determination of endocrine-disrupting chemicals in bottled mineral waters.","journal":"Food chemistry"},{"date":"2021 Jun 14","pmid":"34047317","title":"An automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics.","journal":"The Analyst"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dimethyl phthalate is a small molecule organic compound and phthalate ester that is a colourless and oily liquid. It is poorly soluble in water but soluble in organic solvents, and has been studied in clinical trials for its potential impact on childhood health and wellbeing, particularly in relation to asthma and allergy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}