{"id":"dimethoxanate","rwe":[{"pmid":"17507190","year":"2007","title":"Determination of nifedipine in human plasma and its use in bioequivalence study.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"},{"pmid":"2477524","year":"1989","title":"High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"6865909","year":"1983","title":"High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.","finding":"","journal":"Molecular pharmacology","studyType":"Clinical Study"},{"pmid":"4232803","year":"1967","title":"[Effect of dimethoxanate on the contractility of the isolated guinea pig gallbladder].","finding":"","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales","studyType":"Clinical Study"},{"pmid":"14430450","year":"1959","title":"Clinical evaluation of the antitussive, dimethoxanate.","finding":"","journal":"Medical times","studyType":"Clinical Study"}],"tags":[{"label":"dimethoxanate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DB28","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cotrane","offLabel":[],"synonyms":["dimethoxanate","cotrane","tussidin"],"timeline":[],"approvals":[],"brandName":"Cotrane","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimethoxanate","explanation":"Imagine your body's cells are like locks, and Cotrane is a key that fits into one of those locks. When it binds to the lock, it can either turn it on or off, depending on the type of lock and the key's shape. However, since we don't know what lock Cotrane fits into or how it works, we can't be sure exactly what it does or how it affects the body.","oneSentence":"Cotrane is thought to work by interacting with a specific molecular target, although its exact mechanism of action is currently unknown.","technicalDetail":"Cotrane's mechanism of action is currently unknown, and further research is needed to determine its target and how it interacts with cellular pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/905","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMETHOXANATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:44:09.664829","biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pentoxyverine","drugSlug":"pentoxyverine","fdaApproval":"","relationship":"same-class"},{"drugName":"clofedanol","drugSlug":"clofedanol","fdaApproval":"","relationship":"same-class"}],"genericName":"dimethoxanate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzonatate","brandName":"benzonatate","genericName":"benzonatate","approvalYear":"1958","relationship":"same-class"},{"drugId":"pentoxyverine","brandName":"pentoxyverine","genericName":"pentoxyverine","approvalYear":"","relationship":"same-class"},{"drugId":"clofedanol","brandName":"clofedanol","genericName":"clofedanol","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004676","UNII":"1E3KG5FWDB","CHEBI":"CHEBI:135517","INN_ID":"694","RXNORM":"121069","UMLSCUI":"C0392426","ChEMBL_ID":"CHEMBL2110862","KEGG_DRUG":"D07397","DRUGBANK_ID":"DB13794","PUBCHEM_CID":"10610","SNOMEDCT_US":"30034004"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DB28","allCodes":["R05DB28"]},"biosimilarFilings":[],"recentPublications":[{"date":"2007 Aug 16","pmid":"17507190","title":"Determination of nifedipine in human plasma and its use in bioequivalence study.","journal":"International journal of pharmaceutics"},{"date":"1989 Oct","pmid":"2477524","title":"High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1983 May","pmid":"6865909","title":"High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.","journal":"Molecular pharmacology"},{"date":"1967","pmid":"4232803","title":"[Effect of dimethoxanate on the contractility of the isolated guinea pig gallbladder].","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales"},{"date":"1959 Nov","pmid":"14430450","title":"Clinical evaluation of the antitussive, dimethoxanate.","journal":"Medical times"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cotrane, also known as dimethoxanate, is a small molecule drug of the dimethoxanate class. Its exact target and mechanism of action are unknown, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety profile. Further research is needed to fully understand the properties and potential uses of Cotrane. Due to its lack of FDA approval and limited information, Cotrane is not currently recognized as a commercially available medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}