{"id":"dimethocaine","rwe":[{"pmid":"37141987","year":"2023","title":"The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.","finding":"","journal":"Progress in neuro-psychopharmacology & biological psychiatry","studyType":"Clinical Study"},{"pmid":"25844048","year":"2014","title":"Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer.","finding":"","journal":"International journal of mass spectrometry","studyType":"Clinical Study"},{"pmid":"25445008","year":"2015","title":"Contribution of human esterases to the metabolism of selected drugs of abuse.","finding":"","journal":"Toxicology letters","studyType":"Clinical Study"},{"pmid":"24448968","year":"2014","title":"Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"24309420","year":"2014","title":"Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2.","finding":"","journal":"Toxicology letters","studyType":"Clinical Study"}],"tags":[{"label":"dimethocaine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anesthetics","category":"pharmacology"},{"label":"Anesthetics, Local","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"larocaine","offLabel":[],"synonyms":["dimethocaine","larocaine"],"timeline":[],"approvals":[],"brandName":"Larocaine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimethocaine","explanation":"Imagine your brain is a city with many different streets and intersections. Neurotransmitters are like cars that carry messages between different parts of the city. Larocaine helps keep these cars on the streets longer, allowing them to deliver their messages more effectively.","oneSentence":"Larocaine works by blocking the reuptake of certain neurotransmitters, such as norepinephrine, serotonin, and dopamine, in the brain.","technicalDetail":"Larocaine is a non-selective inhibitor of the norepinephrine, serotonin, and dopamine transporters, which increases the concentration of these neurotransmitters in the synaptic cleft and enhances their activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3154","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dimethocaine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:39:23.933943","biosimilars":[],"competitors":[],"genericName":"dimethocaine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"R3L4A6GOWZ","CHEBI":"CHEBI:135154","UMLSCUI":"C0286889","PUBCHEM_CID":"7177","MESH_SUPPLEMENTAL_RECORD_UI":"C066888"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Aug 30","pmid":"37141987","title":"The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.","journal":"Progress in neuro-psychopharmacology & biological psychiatry"},{"date":"2014 Mar 1","pmid":"25844048","title":"Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer.","journal":"International journal of mass spectrometry"},{"date":"2015 Jan 5","pmid":"25445008","title":"Contribution of human esterases to the metabolism of selected drugs of abuse.","journal":"Toxicology letters"},{"date":"2014 Mar","pmid":"24448968","title":"Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry.","journal":"Analytical and bioanalytical chemistry"},{"date":"2014 Feb 10","pmid":"24309420","title":"Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2.","journal":"Toxicology letters"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dimethocaine, also known as larocaine, is a compound with a stimulatory effect that resembles cocaine but is reportedly less potent. It is listed as a legal cocaine replacement in some countries and is addictive due to its stimulation of the reward pathway in the brain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}