{"id":"dimethisterone","rwe":[{"pmid":"41654892","year":"2026","title":"Multi-omics dynamic profiling reveals predictive biomarkers for first-line immunochemotherapy in extensive-stage small-cell lung cancer.","finding":"","journal":"Journal of translational medicine","studyType":"Clinical Study"},{"pmid":"6481705","year":"1984","title":"Oral contraceptives and neoplasia.","finding":"","journal":"The Journal of reproductive medicine","studyType":"Clinical Study"},{"pmid":"6572785","year":"1983","title":"Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol.","finding":"","journal":"The New England journal of medicine","studyType":"Clinical Study"},{"pmid":"7065054","year":"1982","title":"Effects of oral contraceptives on lipoprotein triglyceride and cholesterol: relationships to estrogen and progestin potency.","finding":"","journal":"American journal of obstetrics and gynecology","studyType":"Clinical Study"},{"pmid":"7298796","year":"1981","title":"Oral contraceptive and postmenopausal estrogen effects on lipoprotein triglyceride and cholesterol in an adult female population: relationships to estrogen and progestin potency.","finding":"","journal":"The Journal of clinical endocrinology and metabolism","studyType":"Clinical Study"}],"tags":[{"label":"dimethisterone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Contraceptive Agents, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Synthetic","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dimethiderome","offLabel":[],"synonyms":["dimethisterone","dimethiderome","dimethisteron"],"timeline":[],"approvals":[],"brandName":"Dimethiderome","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dimethisterone","explanation":"Imagine your body's hormones as a delicate balance of chemicals. Dimethisterone helps to regulate this balance by acting like a natural hormone called progesterone, which is involved in menstrual cycles and pregnancy. By doing so, it can help to treat conditions related to hormone imbalances.","oneSentence":"Dimethisterone works by mimicking the effects of progesterone in the body, influencing hormone balance and reproductive processes.","technicalDetail":"Dimethisterone exerts its effects by binding to progesterone receptors in target tissues, triggering a cascade of downstream signaling events that ultimately influence gene expression and cellular function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/904","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMETHISTERONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:44:04.801811","biosimilars":[],"competitors":[],"genericName":"dimethisterone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001301","UNII":"K4MZ02M175","CHEBI":"CHEBI:4606","UMLSCUI":"C0012391","ChEMBL_ID":"CHEMBL3989718","KEGG_DRUG":"D02298","PUBCHEM_CID":"6607","SECONDARY_CAS_RN":"41354-30-7","MESH_DESCRIPTOR_UI":"D004116"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":46,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 7","pmid":"41654892","title":"Multi-omics dynamic profiling reveals predictive biomarkers for first-line immunochemotherapy in extensive-stage small-cell lung cancer.","journal":"Journal of translational medicine"},{"date":"1984 Jul","pmid":"6481705","title":"Oral contraceptives and neoplasia.","journal":"The Journal of reproductive medicine"},{"date":"1983 Apr 14","pmid":"6572785","title":"Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol.","journal":"The New England journal of medicine"},{"date":"1982 Mar 15","pmid":"7065054","title":"Effects of oral contraceptives on lipoprotein triglyceride and cholesterol: relationships to estrogen and progestin potency.","journal":"American journal of obstetrics and gynecology"},{"date":"1981 Dec","pmid":"7298796","title":"Oral contraceptive and postmenopausal estrogen effects on lipoprotein triglyceride and cholesterol in an adult female population: relationships to estrogen and progestin potency.","journal":"The Journal of clinical endocrinology and metabolism"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dimethisterone is a small molecule with the synonyms 5048, Dimethisteron, Dimethisterone, and Dimethisterone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}