{"id":"dimercaprol","rwe":[],"_fda":{"id":"b970a6fb-f113-3d46-e053-2995a90a28cd","set_id":"0f61111c-5472-45bf-8ce7-a7c4d12fc21b","openfda":{"nui":["N0000000209","N0000000245","N0000175552","N0000175555","N0000175570","M0003647"],"unii":["I76KB35JEV","S6G2NLH4Y7","97C5T2UQ7J","YKH834O4BH","2DI9HA706A","S7YTV04R8O"],"route":["ORAL"],"spl_id":["b970a6fb-f113-3d46-e053-2995a90a28cd"],"brand_name":["TOTAL FEM BAL"],"spl_set_id":["0f61111c-5472-45bf-8ce7-a7c4d12fc21b"],"package_ndc":["61657-2971-1"],"product_ndc":["61657-2971"],"generic_name":["ADRENALINUM, CHOLESTERINUM, FOLLICULINUM, HYPOTHALAMUS, OOPHORINUM, PULSATILLA"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Catecholamines [CS]"],"substance_name":["ANEMONE PULSATILLA","BOS TAURUS HYPOTHALAMUS","CHOLESTEROL","EPINEPHRINE","ESTRONE","SUS SCROFA OVARY"],"pharm_class_epc":["alpha-Adrenergic Agonist [EPC]","beta-Adrenergic Agonist [EPC]","Catecholamine [EPC]"],"pharm_class_moa":["Adrenergic alpha-Agonists [MoA]","Adrenergic beta-Agonists [MoA]"],"manufacturer_name":["White Manufacturing Inc. DBA Micro-West"],"is_original_packager":[true]},"purpose":["For the temporary relief of hormonal imbalances associated with premenstrual syndrome, irregular menstrual cycle, water retention, mild depression, irritability and moodiness. (**)"],"version":"2","warnings":["WARNINGS: • Stop use and call a doctor if symptoms persist or worsen. • If pregnant or breast-feeding, consult a healthcare professional before use. • Keep out of reach of children. • Contains alcohol: in case of accidental overdose, consult a poison control center immediately."],"effective_time":"20210121","active_ingredient":["ACTIVE INGREDIENTS (HPUS*): 100 mL contains 5.55 mL each in 10X, 30X, and LM1 potencies: Adrenalinum, Cholesterinum, Folliculinum, Hypothalamus, Oophorinum, Pulsatilla. *The letters “HPUS” indicate that the components in the product are officially monographed in the Homeopathic Pharmacopeia of the United States."],"inactive_ingredient":["INACTIVE INGREDIENTS: Ethanol (20% v/v), Purified water."],"indications_and_usage":["INDICATIONS: For the temporary relief of hormonal imbalances associated with premenstrual syndrome, irregular menstrual cycle, water retention, mild depression, irritability and moodiness. (**)"],"other_safety_information":["OTHER INFORMATION: Tamper resistant for your protection. Use only if safety seal is intact. (**) Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated"],"dosage_and_administration":["DIRECTIONS: Take 6 drops orally 4 times a day. For ages 12 to adult."],"spl_product_data_elements":["TOTAL FEM BAL Adrenalinum, Cholesterinum, Folliculinum, Hypothalamus, Oophorinum, Pulsatilla ALCOHOL WATER EPINEPHRINE EPINEPHRINE CHOLESTEROL CHOLESTEROL ESTRONE ESTRONE BOS TAURUS HYPOTHALAMUS BOS TAURUS HYPOTHALAMUS SUS SCROFA OVARY SUS SCROFA OVARY ANEMONE PULSATILLA ANEMONE PULSATILLA"],"keep_out_of_reach_of_children":[""],"package_label_principal_display_panel":["NDC 61657-2971-1 MICRO-WEST Homeopathic TOTAL FEM-BAL Product #: 0971 1.0 fl oz (29.6 mL) Ethanol 20% 1.0 fl oz Bottle Label For the temporary relief of hormonal imbalances associated with premenstrual syndrome, irregular menstrual cycle, water retention, mild depression, irritability and moodiness. (**)"]},"tags":[{"label":"Metal Chelator","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V03AB09","category":"atc"},{"label":"Intramuscular","category":"route"},{"label":"Injection","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Accidental poisoning by lead and its compounds and fumes","category":"indication"},{"label":"Gold Toxicity","category":"indication"},{"label":"Mercury Toxicity","category":"indication"},{"label":"Toxic effect of arsenic AND/OR its compounds","category":"indication"},{"label":"Provepharm Sas","category":"company"},{"label":"Approved 1940s","category":"decade"},{"label":"Chelating Agents","category":"pharmacology"},{"label":"Sequestering Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"commonSideEffects":[{"effect":"Rise in blood pressure","drugRate":"","severity":"common","organSystem":""},{"effect":"Tachycardia","drugRate":"","severity":"common","organSystem":""},{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"common","organSystem":""},{"effect":"Headache","drugRate":"","severity":"common","organSystem":""},{"effect":"Burning sensation in lips, mouth and throat","drugRate":"","severity":"common","organSystem":""},{"effect":"Feeling of constriction in throat, chest, or hands","drugRate":"","severity":"common","organSystem":""},{"effect":"Pain in throat, chest, or hands","drugRate":"","severity":"common","organSystem":""},{"effect":"Conjunctivitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Lacrimation","drugRate":"","severity":"common","organSystem":""},{"effect":"Blepharal spasm","drugRate":"","severity":"common","organSystem":""},{"effect":"Rhinorrhea","drugRate":"","severity":"common","organSystem":""},{"effect":"Salivation","drugRate":"","severity":"common","organSystem":""},{"effect":"Tingling of the hands","drugRate":"","severity":"common","organSystem":""},{"effect":"Burning sensation in the penis","drugRate":"","severity":"common","organSystem":""},{"effect":"Sweating of forehead, hands and other areas","drugRate":"","severity":"common","organSystem":""},{"effect":"Abdominal pain","drugRate":"","severity":"common","organSystem":""},{"effect":"Anxiety","drugRate":"","severity":"common","organSystem":""},{"effect":"Weakness","drugRate":"","severity":"common","organSystem":""},{"effect":"Unrest","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Anemia due to enzyme deficiency","Cadmium Toxicity","Deficiency of glucose-6-phosphate dehydrogenase","Disease of liver","Hypertensive disorder","Poisoning by iron AND/OR its compounds"],"specialPopulations":{"Pregnancy":"Pregnancy Category C. Animal reproduction studies have not been conducted with BAL in Oil. It is also not known whether BAL in Oil can cause fetal harm when administered to pregnant woman, or can affect reproduction capacity. BAL in Oil should be given to pregnant woman only if clearly needed.It is not known whether this drug is excreted in human milk. However, because many drugs are excreted in human milk, caution should be exercised when BAL in Oil is administered to nursing woman."},"seriousAdverseEvents":[{"effect":"Painful sterile abscesses","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Provepharm Sas","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=DIMERCAPROL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:22:41.343277+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:22:47.738366+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMERCAPROL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:22:48.211648+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:22:40.100394+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:22:40.100429+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:22:40.100435+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Heavy metals chelating agent","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:22:49.295501+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1597/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:22:48.931745+00:00"}},"allNames":"bal","offLabel":[],"synonyms":["dimercaprol","dithioglycerine","dicaptol"],"timeline":[{"date":"1946-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from AKORN to Provepharm Sas"},{"date":"1946-05-06","type":"positive","source":"DrugCentral","milestone":"FDA approval (Akorn)"}],"approvals":[{"date":"1946-05-06","orphan":false,"company":"AKORN","regulator":"FDA"}],"brandName":"Bal","ecosystem":[{"indication":"Accidental poisoning by lead and its compounds and fumes","otherDrugs":[{"name":"edetic acid","slug":"edetic-acid","company":"Medicis"},{"name":"succimer","slug":"succimer","company":"Recordati Rare"}],"globalPrevalence":null},{"indication":"Gold Toxicity","otherDrugs":[],"globalPrevalence":null},{"indication":"Mercury Toxicity","otherDrugs":[],"globalPrevalence":null},{"indication":"Toxic effect of arsenic AND/OR its compounds","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","moaClass":"Metal Chelating Activity","modality":"Small Molecule","drugClass":"alpha-Adrenergic Agonist [EPC]","explanation":"","oneSentence":"","technicalDetail":"Bal (Dimercaprol) is a trithiol that forms a stable complex with heavy metals such as lead, mercury, and arsenic, facilitating their excretion through the kidneys and gastrointestinal tract."},"commercial":{"launchDate":"1946","_launchSource":"DrugCentral (FDA 1946-05-06, AKORN)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3150","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DIMERCAPROL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMERCAPROL","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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