{"id":"dimephosphon","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Musculoskeletal pain"},{"rate":null,"effect":"Osteonecrosis of the jaw"},{"rate":null,"effect":"Atypical fractures"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a bisphosphonate, dimephosphon binds to hydroxyapatite in bone and is internalized by osteoclasts during bone resorption. Once inside osteoclasts, it inhibits farnesyl pyrophosphate synthase in the mevalonate pathway, disrupting the prenylation of small GTPases essential for osteoclast function and survival. This leads to osteoclast apoptosis and reduced bone turnover, making it useful in conditions characterized by excessive bone loss.","oneSentence":"Dimephosphon is a bisphosphonate that inhibits bone resorption by suppressing osteoclast activity and promoting osteoclast apoptosis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:45:55.016Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis"},{"name":"Paget's disease of bone"},{"name":"Bone metastases"}]},"trialDetails":[{"nctId":"NCT07167550","phase":"PHASE3","title":"The Study of Efficacy and Safety of Dimephosphon® in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Tatchempharmpreparaty, JSC","startDate":"2025-09-06","conditions":"Stroke, Acute Stroke, Ischemic Stroke","enrollment":184}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dimephosphon®","genericName":"Dimephosphon®","companyName":"Tatchempharmpreparaty, JSC","companyId":"tatchempharmpreparaty-jsc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dimephosphon is a bisphosphonate that inhibits bone resorption by suppressing osteoclast activity and promoting osteoclast apoptosis. Used for Osteoporosis, Paget's disease of bone, Bone metastases.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}