{"id":"dimemorfan","rwe":[{"pmid":"39138590","year":"2024","title":"Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.","finding":"","journal":"Redox report : communications in free radical research","studyType":"Clinical Study"},{"pmid":"36724928","year":"2023","title":"[Development of a Simple and Sensitive Enzyme-linked Immunosorbent Assay for Sinomenine].","finding":"","journal":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","studyType":"Clinical Study"},{"pmid":"35611810","year":"2022","title":"Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2.","finding":"","journal":"EMBO molecular medicine","studyType":"Clinical Study"},{"pmid":"28243685","year":"2017","title":"Pharmacokinetics of dimemorfan phosphate tablets in healthy Chinese volunteers.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"25262813","year":"2015","title":"Simple and sensitive LC-MS/MS-based assay for the quantification of dimemorfan in human plasma for use in a pharmacokinetic study.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"}],"tags":[{"label":"dimemorfan","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DA11","category":"atc"},{"label":"Active","category":"status"},{"label":"Antitussive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":63.944,"date":"","count":27,"signal":"Interstitial lung disease","source":"DrugCentral FAERS","actionTaken":"Reported 27 times (LLR=64)"},{"llr":46.954,"date":"","count":19,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 19 times (LLR=47)"},{"llr":39.212,"date":"","count":21,"signal":"Malignant neoplasm progression","source":"DrugCentral FAERS","actionTaken":"Reported 21 times (LLR=39)"}],"commonSideEffects":[{"effect":"Interstitial lung disease","drugRate":"LLR 64","severity":"common"},{"effect":"Hepatic function abnormal","drugRate":"LLR 47","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dimemorphan","offLabel":[],"synonyms":["dimemorfan","dimemorphan","dimemorfan phosphate"],"timeline":[],"approvals":[],"brandName":"Dimemorphan","ecosystem":[],"mechanism":{"target":"Sigma non-opioid intracellular receptor 1","modality":"Small Molecule","drugClass":"dimemorfan","explanation":"Imagine your brain has a volume control for pain. Dimemorfan turns down this volume by activating special receptors that help block pain signals. This can provide relief from discomfort without the need for other medications.","oneSentence":"Dimemorfan works by activating opioid receptors in the brain to reduce pain perception.","technicalDetail":"Dimemorfan is believed to exert its analgesic effects through the activation of mu-opioid receptors, although the exact mechanism of action is not fully understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/900","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DIMEMORFAN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIMEMORFAN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:43:32.426223","biosimilars":[],"competitors":[{"drugName":"hydrocodone","drugSlug":"hydrocodone","fdaApproval":"1943-03-23","patentExpiry":"Sep 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communications in free radical research"},{"date":"2023","pmid":"36724928","title":"[Development of a Simple and Sensitive Enzyme-linked Immunosorbent Assay for Sinomenine].","journal":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan"},{"date":"2022 Jul 7","pmid":"35611810","title":"Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2.","journal":"EMBO molecular medicine"},{"date":"2017 Jun","pmid":"28243685","title":"Pharmacokinetics of dimemorfan phosphate tablets in healthy Chinese volunteers.","journal":"European journal of clinical pharmacology"},{"date":"2015 May","pmid":"25262813","title":"Simple and sensitive LC-MS/MS-based assay for the quantification of dimemorfan in human plasma for use in a pharmacokinetic study.","journal":"Biomedical chromatography : BMC"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dimemorfan, a small molecule drug in the dimemorfan class, is a centrally acting analgesic with an unknown target. Its mechanism of action is not well-documented, and it has not been approved by the FDA for any indications. The current owner of dimemorfan is unknown, and its commercial status is unclear. Further research is needed to fully understand its pharmacological properties and potential clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}