{"id":"diluted-deodorized-tincture-of-opium","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dependence potential"}]},"_chembl":{"chemblId":"CHEMBL2107915","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DDO contains alkaloids from opium poppies, primarily morphine, which act as agonists at mu, delta, and kappa opioid receptors. This receptor activation reduces pain perception and decreases gastrointestinal motility. The deodorized formulation removes volatile compounds while retaining the active opioid alkaloids, making it suitable for oral administration in clinical settings.","oneSentence":"Diluted Deodorized Tincture of Opium (DDO) is an opioid preparation that binds to opioid receptors in the central and peripheral nervous system to produce analgesia and antidiarrheal effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:17.068Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diarrhea management"},{"name":"Pain relief"}]},"trialDetails":[{"nctId":"NCT01723722","phase":"PHASE4","title":"Treatment of Neonatal Abstinence Syndrome","status":"COMPLETED","sponsor":"Eastern Maine Medical Center","startDate":"2007-01","conditions":"Neonatal Abstinence Syndrome","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Laudanum"],"phase":"marketed","status":"active","brandName":"Diluted Deodorized Tincture of Opium","genericName":"Diluted Deodorized Tincture of Opium","companyName":"Eastern Maine Medical Center","companyId":"eastern-maine-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diluted Deodorized Tincture of Opium (DDO) is an opioid preparation that binds to opioid receptors in the central and peripheral nervous system to produce analgesia and antidiarrheal effects. Used for Diarrhea management, Pain relief.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}