{"id":"diltiazem-treated-group","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Headache"},{"rate":"3-10","effect":"Dizziness"},{"rate":"2-8","effect":"Constipation"},{"rate":"2-4","effect":"Edema"},{"rate":"2-5","effect":"Bradycardia"},{"rate":"1-3","effect":"Asthenia/fatigue"}]},"_chembl":{"chemblId":"CHEMBL1200805","moleculeType":"Small molecule","molecularWeight":"548.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits the inward movement of calcium ions through L-type calcium channels in the sinoatrial and atrioventricular nodes, as well as in vascular smooth muscle. This results in decreased automaticity and conduction velocity in the heart, reduced myocardial contractility, and vasodilation of coronary and peripheral arteries. These effects collectively reduce heart rate, lower blood pressure, and improve myocardial oxygen supply-demand balance.","oneSentence":"Diltiazem blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx and decreasing heart rate and blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:16.390Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Atrial fibrillation with rapid ventricular response"}]},"trialDetails":[{"nctId":"NCT02479204","phase":"PHASE1","title":"Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441","status":"TERMINATED","sponsor":"Viatris Innovation GmbH","startDate":"2015-04-28","conditions":"Healthy Subjects","enrollment":10},{"nctId":"NCT04153032","phase":"PHASE2","title":"Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the 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Angina","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Diltiazem treated group","genericName":"Diltiazem treated group","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diltiazem blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx and decreasing heart rate and blood pressure. Used for Hypertension, Angina pectoris, Atrial fibrillation with rapid ventricular response.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}