{"id":"diltiazem-injectable-product","brandName":"Diltiazem Injectable Product","genericName":"Diltiazem Injectable Product","companyId":"virginia-commonwealth-university","companyName":"Virginia Commonwealth University","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Diltiazem Injectable Product is a calcium channel blocker used primarily for acute management of cardiovascular conditions such as atrial fibrillation and hypertension. It has been studied in several Phase 3 and 4 trials, demonstrating efficacy and safety in emergency settings. The drug is not currently FDA-approved but has off-label use supported by clinical evidence.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diltiazem blocks L-type calcium channels in the sinoatrial and atrioventricular nodes, slowing conduction and reducing heart rate. It also causes vasodilation of coronary and peripheral arteries by blocking calcium entry into vascular smooth muscle, thereby reducing myocardial oxygen demand and improving coronary blood flow. The injectable formulation provides rapid onset for acute management of arrhythmias and hypertensive episodes.","oneSentence":"Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits calcium influx into cardiac and vascular smooth muscle cells, reducing heart rate and blood pressure.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"5-10","effect":"Hypotension"},{"rate":"2-5","effect":"Bradycardia"},{"rate":"3-8","effect":"Dizziness"},{"rate":"2-5","effect":"Headache"},{"rate":"1-3","effect":"Flushing"},{"rate":"<1","effect":"Asystole or severe AV block"}]},"trials":[],"indications":{"approved":[{"name":"Atrial fibrillation with rapid ventricular response"},{"name":"Paroxysmal supraventricular tachycardia"},{"name":"Hypertensive crisis"},{"name":"Angina pectoris"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}