{"id":"diloxanide-furoate","rwe":[{"pmid":"41062221","year":"2025","title":"Entamoeba histolytica carbonic anhydrase.","finding":"","journal":"The Enzymes","studyType":"Clinical Study"},{"pmid":"39872767","year":"2025","title":"Rectal ameboma: A new entity in the differential diagnosis of rectal cancer.","finding":"","journal":"World journal of gastrointestinal surgery","studyType":"Clinical Study"},{"pmid":"39564686","year":"2025","title":"Diloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness.","finding":"","journal":"Basic & clinical pharmacology & toxicology","studyType":"Clinical Study"},{"pmid":"37979746","year":"2024","title":"Chitosan-based intelligent polymeric networks for site-specific colon medication delivery: A comprehensive study on controlled release of diloxanide furoate and network formation dynamics.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"30137820","year":"2026","title":"Amebiasis(Archived).","finding":"","journal":"","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Amebic infection","category":"indication"},{"label":"Amebicides","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"furamide","offLabel":[],"synonyms":["diloxanide furoate","amebiazol","dichlofurazol","diclofurazol","diloxanid furoate","entamide furoate","furamide","furentomin"],"timeline":[],"aiSummary":"Furamide, also known as diloxanide furoate, is a small molecule medication used to treat amebic infections. Its exact mechanism of action is not well understood, but it is believed to work by inhibiting the growth of the ameba parasite. Furamide is not FDA-approved, but it is available as a generic medication. Key safety considerations include the potential for gastrointestinal side effects. As a generic medication, its commercial status is not patented.","approvals":[],"brandName":"Furamide","ecosystem":[{"indication":"Amebic infection","otherDrugs":[{"name":"diiodohydroxyquinoline","slug":"diiodohydroxyquinoline","company":""},{"name":"sulfacetamide","slug":"sulfacetamide","company":"Ortho Mcneil Pharm"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body as a city, and the ameba parasite as a weed that's taking over. Furamide is like a weed killer that stops the weed from growing and spreading. It helps your body's natural defenses to get rid of the parasite.","oneSentence":"Furamide works by inhibiting the growth of the ameba parasite.","technicalDetail":"Furamide is a luminal amebicide that acts by inhibiting the growth of Entamoeba histolytica, the causative agent of amebic infections."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/896","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diloxanide furoate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:43:17.841569","biosimilars":[],"competitors":[],"genericName":"diloxanide furoate","indications":{"approved":[{"name":"Amebic infection","source":"DrugCentral","snomedId":111910009,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002955","UNII":"YP4N72IW34","CHEBI":"CHEBI:4601","RXNORM":"23203","UMLSCUI":"C0058181","ChEMBL_ID":"CHEMBL1334860","KEGG_DRUG":"D02480","DRUGBANK_ID":"DB14638","PUBCHEM_CID":"19529","SNOMEDCT_US":"396029009","SECONDARY_CAS_RN":"579-38-4","MESH_SUPPLEMENTAL_RECORD_UI":"C004932"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":72,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"41062221","title":"Entamoeba histolytica carbonic anhydrase.","journal":"The Enzymes"},{"date":"2025 Jan 27","pmid":"39872767","title":"Rectal ameboma: A new entity in the differential diagnosis of rectal cancer.","journal":"World journal of gastrointestinal surgery"},{"date":"2025 Jan","pmid":"39564686","title":"Diloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness.","journal":"Basic & clinical pharmacology & toxicology"},{"date":"2024 Jan","pmid":"37979746","title":"Chitosan-based intelligent polymeric networks for site-specific colon medication delivery: A comprehensive study on controlled release of diloxanide furoate and network formation dynamics.","journal":"International journal of biological macromolecules"},{"date":"2026 Jan","pmid":"30137820","title":"Amebiasis(Archived).","journal":""}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}