{"id":"dilaudid-injectable-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL2094006","moleculeType":"Small molecule","molecularWeight":"702.93"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydromorphone is a semi-synthetic opioid derived from morphine that acts as a mu opioid receptor agonist. By binding to mu receptors in the brain and spinal cord, it modulates pain perception and produces analgesic effects. The injectable formulation allows for rapid onset of action and is used for acute and severe pain management in clinical settings.","oneSentence":"Dilaudid (hydromorphone) is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:16.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Severe chronic pain in opioid-tolerant patients"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT03214510","phase":"PHASE3","title":"Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2017-10-04","conditions":"Liver and Intrahepatic Bile Duct Disorder","enrollment":101},{"nctId":"NCT03715517","phase":"NA","title":"Spinal Anesthesia For Enhanced Recovery After Liver Surgery","status":"RECRUITING","sponsor":"University of Manitoba","startDate":"2018-10-04","conditions":"Hepatectomy, Pain, Postoperative, Liver Neoplasms","enrollment":128},{"nctId":"NCT06411795","phase":"PHASE2","title":"Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy","status":"RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2023-11-10","conditions":"Duodenal Neoplasm, Pancreatic Neoplasm","enrollment":78},{"nctId":"NCT07348627","phase":"PHASE3","title":"Opioid-Sparing Joint Replacement","status":"NOT_YET_RECRUITING","sponsor":"Emory University","startDate":"2026-02","conditions":"Pain Management, Opioid Consumption","enrollment":120},{"nctId":"NCT03743194","phase":"PHASE4","title":"Pectoralis and Serratus Muscle Blocks","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2021-12-14","conditions":"Post Operative Pain Control","enrollment":210},{"nctId":"NCT04606264","phase":"PHASE3","title":"Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data","status":"COMPLETED","sponsor":"Jennifer Holder-Murray","startDate":"2023-05-15","conditions":"Perioperative Optimization","enrollment":2977},{"nctId":"NCT06823180","phase":"PHASE4","title":"Hydromorphone Hydrochloride Epidural Preemptive Analgesia for Postoperative Pain After Cesarean Section","status":"COMPLETED","sponsor":"Liquan Liang","startDate":"2025-03-03","conditions":"Post-surgical Pain","enrollment":105},{"nctId":"NCT04240626","phase":"PHASE4","title":"Multimodal Analgesia Effect on Post Surgical Patient","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, Davis","startDate":"2021-01-20","conditions":"Obesity, Morbid, Surgery, Bariatric Surgery Candidate","enrollment":60},{"nctId":"NCT04300231","phase":"PHASE3","title":"Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy","status":"COMPLETED","sponsor":"Indiana University","startDate":"2019-10-22","conditions":"Cystectomy","enrollment":160},{"nctId":"NCT03987022","phase":"PHASE4","title":"ICE-T Pain Regimen for Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2019-08-01","conditions":"Opioid Substitution Treatment","enrollment":66},{"nctId":"NCT04258631","phase":"PHASE4","title":"Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2020-07-09","conditions":"Malignant Female Reproductive System Neoplasm","enrollment":105},{"nctId":"NCT03789318","phase":"PHASE2","title":"Study in Subjects Undergoing Complete Abdominoplasty","status":"COMPLETED","sponsor":"Concentric Analgesics","startDate":"2018-12-03","conditions":"Postsurgical Pain","enrollment":54},{"nctId":"NCT05579223","phase":"PHASE2","title":"Intrathecal Hydromorphone for Postoperative Pain of Anorectal Surgery","status":"COMPLETED","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2022-10-17","conditions":"Acute Pain, Post Operative Pain, Anorectal Disorder","enrollment":150},{"nctId":"NCT01848951","phase":"","title":"Comparison of Epidural and TAP Block in Abdominal Surgery","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2014-02-01","conditions":"Acute Pain, Surgery, Regional Anesthesia","enrollment":72},{"nctId":"NCT03972397","phase":"PHASE4","title":"Intercostal Nerve Cryoablation for Postoperative Pain Management","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2019-07-15","conditions":"Pain, Postoperative","enrollment":20},{"nctId":"NCT05848635","phase":"PHASE4","title":"Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled","status":"UNKNOWN","sponsor":"Qianfoshan Hospital","startDate":"2023-05-01","conditions":"Pulmonary Nodule, Ablation","enrollment":88},{"nctId":"NCT03933865","phase":"PHASE1","title":"Acute Pain Management in Patients on Opioid Replacement Therapy","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2018-10-31","conditions":"Opioid-use Disorder, Pain, Acute","enrollment":1},{"nctId":"NCT04613869","phase":"NA","title":"The Effect of Esketamine on Patients Undergoing Tumor Surgery","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2020-08-15","conditions":"Tumor Surgery","enrollment":282},{"nctId":"NCT02178553","phase":"PHASE4","title":"Study of Exparel Versus Epidural for Pain Control After Thoracotomy","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2014-10-15","conditions":"Pain Following Thoracotomy Surgery","enrollment":102},{"nctId":"NCT02356198","phase":"NA","title":"Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2015-03","conditions":"Conditions Requiring Colorectal Surgery","enrollment":209},{"nctId":"NCT02111746","phase":"PHASE4","title":"PAIN - Postoperative Analgesia INvestigation","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2013-11-20","conditions":"Postoperative Pain","enrollment":350},{"nctId":"NCT02044094","phase":"PHASE2","title":"Multiple Dose Study of Blockade of Opioid Effects by Injections of Buprenorphine in Participants With Opioid Disorder","status":"COMPLETED","sponsor":"Indivior Inc.","startDate":"2013-11","conditions":"Opioid Use Disorder","enrollment":39},{"nctId":"NCT02164929","phase":"NA","title":"Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy","status":"TERMINATED","sponsor":"Duke University","startDate":"2013-12","conditions":"Laparoscopic Colorectal Resection","enrollment":17},{"nctId":"NCT02372591","phase":"PHASE1","title":"Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2015-08","conditions":"Opioid-Related Disorders, Chronic Pain","enrollment":14},{"nctId":"NCT01642030","phase":"PHASE1","title":"Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2013-08","conditions":"Opioid Dependence, Pain, Addiction","enrollment":132},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226},{"nctId":"NCT01218984","phase":"PHASE2","title":"ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids","status":"COMPLETED","sponsor":"Alkermes, Inc.","startDate":"2002-03","conditions":"Opiate Dependence","enrollment":27},{"nctId":"NCT02572804","phase":"NA","title":"Comparing Rectus Sheath Catheter to Epidural Post Cystectomy","status":"UNKNOWN","sponsor":"Vancouver Coastal Health","startDate":"2015-09","conditions":"Bladder Cancer, Postoperative Pain","enrollment":160},{"nctId":"NCT01447212","phase":"PHASE3","title":"Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2011-12","conditions":"Opioid Dependence, Heroin Dependence","enrollment":202},{"nctId":"NCT01932554","phase":"PHASE2","title":"Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis","status":"WITHDRAWN","sponsor":"St. Louis University","startDate":"2013-11","conditions":"Sickle Cell Disease, Hb-SS Disease With Vasoocclusive Pain, Hemoglobin SS Disease With Vasoocclusive Crisis","enrollment":""},{"nctId":"NCT01582490","phase":"PHASE4","title":"Study of EXPAREL in Patients Undergoing Breast Augmentation","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2012-04","conditions":"Mammoplasty, Postoperative Pain","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hydromorphone"],"phase":"marketed","status":"active","brandName":"Dilaudid Injectable Product","genericName":"Dilaudid Injectable Product","companyName":"University of California, Davis","companyId":"university-of-california-davis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dilaudid Injectable Product is a small molecule used to treat various conditions, including pain following thoracotomy surgery, post-surgical pain, and acute pain. It is administered through interventions such as neuraxial analgesia and regional block, and has also been studied for use in opioid-use disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":4,"withResults":3},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}