{"id":"diiodohydroxyquinoline","rwe":[{"pmid":"41861738","year":"2026","title":"Towards safer foods: a high-performance quercetin-based potentiometric sensor for aluminum detection.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"40430583","year":"2025","title":"Correction: Kamel et al. Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors. Pharmaceuticals 2022, 15, 251.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"36510496","year":"2023","title":"Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and remdesivir as potential inhibitors against RNA dependent RNA polymerase of SARS-CoV-2: A comparative in silico perspective.","finding":"","journal":"Informatics in medicine unlocked","studyType":"Clinical Study"},{"pmid":"35215363","year":"2022","title":"Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"34568544","year":"2021","title":"Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approach.","finding":"","journal":"Informatics in medicine unlocked","studyType":"Clinical Study"}],"tags":[{"label":"diiodohydroxyquinoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Mitogen-activated protein kinase 1","category":"target"},{"label":"MAPK1","category":"gene"},{"label":"MAPK14","category":"gene"},{"label":"ADORA3","category":"gene"},{"label":"G01AC01","category":"atc"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Gel","category":"form"},{"label":"Active","category":"status"},{"label":"Amebic infection","category":"indication"},{"label":"Amebicides","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[],"contraindications":["Adrenal cortical hypofunction","Atrophoderma","Disease of liver","Optic neuritis","Peripheral nerve disease","Peripheral vascular disease","Telangiectasia disorder"],"specialPopulations":{"Pregnancy":"Pregnancy Category C. Animal reproductive studies have not been conducted with ALOQUIN. It is not known whether ALOQUIN can cause fetal harm when administered to pregnant women or can affect reproductive capacity. ALOQUIN should be given to pregnant women only if clearly needed.","Paediatric use":"Safety and effectiveness in pediatric patients below the age of 12 have not been established."}},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=diiodohydroxyquinoline","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:53:45.998050+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:53:51.139460+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diiodohydroxyquinoline","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:53:51.453945+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL86754/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:53:52.157954+00:00"}},"allNames":"diiodoquin","offLabel":[],"synonyms":["iodoquinol","diiodohydroxyquinoline","diiodohydroxyquin","diiodoquin","diiodoquinol"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Diiodoquin","ecosystem":[{"indication":"Amebic infection","otherDrugs":[{"name":"sulfacetamide","slug":"sulfacetamide","company":"Ortho Mcneil Pharm"}],"globalPrevalence":null}],"mechanism":{"target":"Mitogen-activated protein kinase 1","novelty":"First-in-class","targets":[{"gene":"MAPK1","source":"DrugCentral","target":"Mitogen-activated protein kinase 1","protein":"Mitogen-activated protein kinase 1"},{"gene":"MAPK14","source":"DrugCentral","target":"Mitogen-activated protein kinase 14","protein":"Mitogen-activated protein kinase 14"},{"gene":"ADORA3","source":"DrugCentral","target":"Adenosine receptor A3","protein":"Adenosine receptor A3"},{"gene":"FYN","source":"DrugCentral","target":"Tyrosine-protein kinase Fyn","protein":"Tyrosine-protein kinase Fyn"},{"gene":"EGFR","source":"DrugCentral","target":"Epidermal growth factor receptor","protein":"Epidermal growth factor receptor"},{"gene":"LCK","source":"DrugCentral","target":"Tyrosine-protein kinase Lck","protein":"Tyrosine-protein kinase Lck"},{"gene":"MAPK3","source":"DrugCentral","target":"Mitogen-activated protein kinase 3","protein":"Mitogen-activated protein kinase 3"},{"gene":"ERBB2","source":"DrugCentral","target":"Receptor tyrosine-protein kinase erbB-2","protein":"Receptor tyrosine-protein kinase erbB-2"}],"modality":"Small Molecule","drugClass":"diiodohydroxyquinoline","explanation":"","oneSentence":"","technicalDetail":"Diiodoquin exerts its effects by binding to the mitogen-activated protein kinase 1 enzyme, thereby inhibiting its activity and disrupting the signaling pathways involved in parasite replication."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1457","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diiodohydroxyquinoline","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:37:33.377747","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:53:53.747531+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"clioquinol","drugSlug":"clioquinol","fdaApproval":"","relationship":"same-class"},{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-class"}],"genericName":"diiodohydroxyquinoline","indications":{"approved":[{"name":"Amebic infection","source":"DrugCentral","snomedId":111910009,"regulator":"FDA"}],"offLabel":[{"name":"Atopic dermatitis","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":1,"evidenceLevel":"emerging"},{"name":"Contact dermatitis","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":1,"evidenceLevel":"emerging"},{"name":"Eruption of skin","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":0,"evidenceLevel":"emerging"},{"name":"Lichen simplex chronicus","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":0,"evidenceLevel":"emerging"},{"name":"Pruritus ani","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":0,"evidenceLevel":"emerging"},{"name":"Pruritus of genital organs","source":"DrugCentral","drugName":"diiodohydroxyquinoline","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clioquinol","brandName":"clioquinol","genericName":"clioquinol","approvalYear":"","relationship":"same-class"},{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Cream, Gel","formulations":[{"form":"CREAM","route":"TOPICAL","productName":"Hydrocortisone Iodoquinol"},{"form":"CREAM","route":"TOPICAL","productName":"HYDROCORTISONE IODOQUINOL"},{"form":"CREAM","route":"TOPICAL","productName":"Corti-Sav"},{"form":"CREAM","route":"TOPICAL","productName":"HYDROCORTISONE 2.5% / IODOQUINOL 1% / KETOCONAZOLE 2%"},{"form":"CREAM","route":"TOPICAL","productName":"HYDROCORTISONE, IODOQUINOL"},{"form":"CREAM","route":"TOPICAL","productName":"Hydrocortisone Acetate, Iodoquinol"},{"form":"CREAM","route":"TOPICAL","productName":"SKYNPLEX"},{"form":"CREAM","route":"TOPICAL","productName":"Vytone"},{"form":"GEL","route":"TOPICAL","productName":"IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES"},{"form":"GEL","route":"TOPICAL","productName":"Alcortin A"},{"form":"GEL","route":"TOPICAL","productName":"Aloquin"},{"form":"GEL","route":"TOPICAL","productName":"Alcortin"},{"form":"GEL","route":"TOPICAL","productName":"IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES"},{"form":"GEL","route":"TOPICAL","productName":"IODOQUINOL, HYDROCORTISONE ACETATE, ALOE POLYSACCHARIDES"}]},"crossReferences":{"NUI":"N0000146916","MMSL":"2439","NDDF":"002952","UNII":"63W7IE88K8","VUID":"4018600","CHEBI":"CHEBI:5950","VANDF":"4018600","INN_ID":"1613","RXNORM":"3435","UMLSCUI":"C0012341","chemblId":"CHEMBL86754","ChEMBL_ID":"CHEMBL86754","KEGG_DRUG":"D00581","DRUGBANK_ID":"DB09115","PUBCHEM_CID":"3728","SNOMEDCT_US":"387355005","MESH_DESCRIPTOR_UI":"D004103"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":79,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"G01AC01","allCodes":["G01AC01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 4","pmid":"41861738","title":"Towards safer foods: a high-performance quercetin-based potentiometric sensor for aluminum detection.","journal":"Food chemistry"},{"date":"2025 Apr 28","pmid":"40430583","title":"Correction: Kamel et al. Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors. Pharmaceuticals 2022, 15, 251.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2023","pmid":"36510496","title":"Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and remdesivir as potential inhibitors against RNA dependent RNA polymerase of SARS-CoV-2: A comparative in silico perspective.","journal":"Informatics in medicine unlocked"},{"date":"2022 Feb 19","pmid":"35215363","title":"Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2021","pmid":"34568544","title":"Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approach.","journal":"Informatics in medicine unlocked"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diiodoquin is a small molecule with the chemical name diiodohydroxyquinoline, used in the treatment of amoebiasis. It is a quinoline derivative with various synonyms, including DIIODOHIDROXIQUINOLEINA and DIIODOHYDROXYQUINOLINE.","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:53:53.747531+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}