{"id":"dihydrotachysterol","rwe":[],"tags":[{"label":"dihydrotachysterol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Vitamin D3 receptor","category":"target"},{"label":"VDR","category":"gene"},{"label":"A11CC02","category":"atc"},{"label":"Active","category":"status"},{"label":"Hypocalcemia","category":"indication"},{"label":"Hypoparathyroidism","category":"indication"},{"label":"Hypophosphatemia","category":"indication"},{"label":"Rickets","category":"indication"},{"label":"Tetany","category":"indication"},{"label":"Bone Density Conservation Agents","category":"pharmacology"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"phase_2","safety":{"contraindications":["Arteriosclerosis obliterans","Hypercalcemia","Hyperphosphatemia","Hypervitaminosis D","Kidney disease","Kidney stone","Sarcoidosis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dichystrolum","offLabel":[],"synonyms":["dihydrotachysterol","dichystrolum"],"timeline":[],"approvals":[],"brandName":"Dichystrolum","ecosystem":[{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Hypoparathyroidism","otherDrugs":[{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"colecalciferol","slug":"colecalciferol","company":"Sandoz"},{"name":"ergocalciferol","slug":"ergocalciferol","company":"Sanofi Aventis Us"},{"name":"parathyroid hormone","slug":"parathyroid-hormone","company":"Nps Pharms Inc"}],"globalPrevalence":null},{"indication":"Hypophosphatemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"sodium glycerophosphate","slug":"sodium-glycerophosphate","company":"Fresenius Kabi Usa"},{"name":"sodium phosphate, monobasic","slug":"sodium-phosphate,-monobasic","company":""}],"globalPrevalence":null},{"indication":"Rickets","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"colecalciferol","slug":"colecalciferol","company":"Sandoz"},{"name":"ergocalciferol","slug":"ergocalciferol","company":"Sanofi Aventis Us"}],"globalPrevalence":null},{"indication":"Tetany","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Vitamin D3 receptor","targets":[{"gene":"VDR","source":"DrugCentral","target":"Vitamin D3 receptor","protein":"Vitamin D3 receptor"}],"modality":"Small Molecule","drugClass":"dihydrotachysterol","explanation":"Think of Vitamin D3 like a key that unlocks a door to allow calcium to enter your cells. When Dichystrolum binds to the Vitamin D3 receptor, it's like giving the key to the door, allowing calcium to flow in and helping to regulate your body's calcium levels.","oneSentence":"Dichystrolum works by activating the Vitamin D3 receptor to increase calcium levels in the body.","technicalDetail":"Dichystrolum acts as a selective agonist of the Vitamin D3 receptor, which is a nuclear receptor that regulates the expression of genes involved in calcium homeostasis, including those involved in calcium absorption and bone 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