{"id":"dihydroartemisinine-piperaquine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL539666","moleculeType":"Small molecule","molecularWeight":"633.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroartemisinin, a semi-synthetic derivative of artemisinin, generates reactive oxygen species within malaria parasites that damage parasite proteins and DNA, leading to rapid parasite clearance. Piperaquine is a bisquinoline that accumulates in the parasite's food vacuole and inhibits heme detoxification, causing parasite death. Together, they provide rapid symptom relief and sustained cure with reduced recrudescence risk.","oneSentence":"Dihydroartemisinin-piperaquine is a fixed-dose antimalarial combination that kills malaria parasites through multiple mechanisms: dihydroartemisinin acts as a fast-acting artemisinin derivative, while piperaquine provides sustained parasite suppression.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:15.634Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Uncomplicated malaria caused by Plasmodium vivax"},{"name":"Uncomplicated malaria caused by other Plasmodium species"}]},"trialDetails":[{"nctId":"NCT07470424","phase":"PHASE1","title":"A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults","status":"NOT_YET_RECRUITING","sponsor":"University of 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