{"id":"digitalin","rwe":[{"pmid":"41508199","year":"2025","title":"[Research progress on chemical constituents, pharmacological effects, and clinical application of classic Taohong Siwu Decoction and predictive analysis of quality markers].","finding":"","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","studyType":"Clinical Study"},{"pmid":"30000905","year":"2006","title":"Digoxin.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"23722601","year":"2014","title":"Steroidal glycosides with antiproliferative activities from Digitalis trojana.","finding":"","journal":"Phytotherapy research : PTR","studyType":"Clinical Study"},{"pmid":"17128524","year":"2006","title":"Treprostinil: new drug. Pulmonary artery hypertension: just another (disappointing) prostacycline analogue.","finding":"","journal":"Prescrire international","studyType":"Clinical Study"},{"pmid":"16981216","year":"2007","title":"Acenocoumarol and vasculitis: a case report.","finding":"","journal":"Pharmacoepidemiology and drug safety","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diginorgin","offLabel":[],"synonyms":["digitalin","diginorgin","glucostrospeside"],"timeline":[],"approvals":[],"brandName":"Diginorgin","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your heart cells have a special pump that helps them relax and contract. Digitalin blocks this pump, causing the cells to take in more calcium, which makes them contract more strongly. This can help the heart beat more efficiently, but it can also have negative effects if not used carefully.","oneSentence":"Digitalin works by inhibiting the sodium-potassium pump in cardiac cells, leading to increased intracellular calcium levels and subsequent contraction.","technicalDetail":"Digitalin is a cardiac glycoside that acts as a competitive inhibitor of the sodium-potassium ATPase pump, leading to increased intracellular sodium and calcium levels, and subsequent enhancement of cardiac contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3143","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=digitalin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:42:11.160678","biosimilars":[],"competitors":[],"genericName":"digitalin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006651","UNII":"Q15ECE254B","CHEBI":"CHEBI:28143","RXNORM":"1923401","UMLSCUI":"C0058012","ChEMBL_ID":"CHEMBL505674","PUBCHEM_CID":"441856","MESH_SUPPLEMENTAL_RECORD_UI":"C034791"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":53,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Oct","pmid":"41508199","title":"[Research progress on chemical constituents, pharmacological effects, and clinical application of classic Taohong Siwu Decoction and predictive analysis of quality markers].","journal":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica"},{"date":"2006","pmid":"30000905","title":"Digoxin.","journal":""},{"date":"2014 Apr","pmid":"23722601","title":"Steroidal glycosides with antiproliferative activities from Digitalis trojana.","journal":"Phytotherapy research : PTR"},{"date":"2006 Oct","pmid":"17128524","title":"Treprostinil: new drug. Pulmonary artery hypertension: just another (disappointing) prostacycline analogue.","journal":"Prescrire international"},{"date":"2007 Jan","pmid":"16981216","title":"Acenocoumarol and vasculitis: a case report.","journal":"Pharmacoepidemiology and drug safety"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diginorgin, also known as digitalin, is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it is not FDA approved for any indications. The drug's pharmacokinetic properties, including half-life and bioavailability, are also unknown. As a result, there is limited information available on its safety profile and generic availability. Further research is needed to fully understand the properties and potential uses of diginorgin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}