{"id":"diflucortolone","rwe":[{"pmid":"41709500","year":"2026","title":"Investigating the Telomerase Downregulatory Potential of Steroidal Drugs Following Pharmacophore-Based Rational; Computational and In Vitro Assessments.","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"39198945","year":"2024","title":"[Simultaneous determination of 61 hormones in water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry].","finding":"","journal":"Se pu = Chinese journal of chromatography","studyType":"Clinical Study"},{"pmid":"38501938","year":"2024","title":"Efficacy and safety of topical corticosteroid treatment under occlusion for severe alopecia areata in children: a single-centre retrospective analysis.","finding":"","journal":"Clinical and experimental dermatology","studyType":"Clinical Study"},{"pmid":"36788666","year":"2023","title":"Betamethasone cream to treat diapers rash causing Cushing syndrome.","finding":"","journal":"Journal of pediatric endocrinology & metabolism : JPEM","studyType":"Clinical Study"},{"pmid":"33554496","year":"2020","title":"Cushing syndrome induced by long term use of corticosteroids in the management of atopic dermatitis.","finding":"","journal":"Pediatric endocrinology, diabetes, and metabolism","studyType":"Clinical Study"}],"tags":[{"label":"diflucortolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D07AC06","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"difluocortolone","offLabel":[],"synonyms":["diflucortolone","difluocortolone"],"timeline":[],"approvals":[],"brandName":"Difluocortolone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"diflucortolone","explanation":"Imagine your body's immune system as a fire alarm that sounds when it detects something wrong. Cortisol is like a fire chief that comes to put out the fire, but also makes sure the alarm doesn't go off unnecessarily. Difluocortolone is like a fake fire chief that does the same job, but in a controlled way to help with inflammation and immune system issues.","oneSentence":"Difluocortolone works by mimicking the effects of cortisol in the body to reduce inflammation and suppress the immune system.","technicalDetail":"Difluocortolone is a synthetic corticosteroid that acts as a glucocorticoid receptor agonist, leading to the transcriptional regulation of genes involved in inflammation and immune response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3141","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=DIFLUCORTOLONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIFLUCORTOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:36:11.969236","biosimilars":[],"competitors":[{"drugName":"betamethasone","drugSlug":"betamethasone","fdaApproval":"1961-04-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"desoximetasone","drugSlug":"desoximetasone","fdaApproval":"1977-02-28","patentExpiry":"Sep 1, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluocinolone acetonide","drugSlug":"fluocinolone-acetonide","fdaApproval":"1963-02-15","patentExpiry":"Nov 7, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fludroxycortide","drugSlug":"fludroxycortide","fdaApproval":"1963-03-19","relationship":"same-class"},{"drugName":"fluocinonide","drugSlug":"fluocinonide","fdaApproval":"1971-06-30","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"budesonide","drugSlug":"budesonide","fdaApproval":"1994-02-14","patentExpiry":"Sep 9, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diflorasone diacetate","drugSlug":"diflorasone-diacetate","fdaApproval":"1977-09-14","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"amcinonide","drugSlug":"amcinonide","fdaApproval":"1979-10-18","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mometasone furoate","drugSlug":"mometasone-furoate","fdaApproval":"1987-04-30","patentExpiry":"Oct 3, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"beclometasone dipropionate","drugSlug":"beclometasone-dipropionate","fdaApproval":"1976-05-12","relationship":"same-class"},{"drugName":"hydrocortisone aceponate","drugSlug":"hydrocortisone-aceponate","fdaApproval":"","relationship":"same-class"},{"drugName":"fluticasone furoate","drugSlug":"fluticasone-furoate","fdaApproval":"2007-04-27","patentExpiry":"Oct 15, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluticasone propionate","drugSlug":"fluticasone-propionate","fdaApproval":"1990-12-14","patentExpiry":"Sep 26, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prednicarbate","drugSlug":"prednicarbate","fdaApproval":"1991-09-23","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"difluprednate","drugSlug":"difluprednate","fdaApproval":"2008-06-23","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ulobetasol propionate","drugSlug":"ulobetasol-propionate","fdaApproval":"1990-12-17","relationship":"same-class"}],"genericName":"diflucortolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-class"},{"drugId":"desoximetasone","brandName":"desoximetasone","genericName":"desoximetasone","approvalYear":"1977","relationship":"same-class"},{"drugId":"fluocinolone-acetonide","brandName":"fluocinolone acetonide","genericName":"fluocinolone acetonide","approvalYear":"1963","relationship":"same-class"},{"drugId":"fludroxycortide","brandName":"fludroxycortide","genericName":"fludroxycortide","approvalYear":"1963","relationship":"same-class"},{"drugId":"fluocinonide","brandName":"fluocinonide","genericName":"fluocinonide","approvalYear":"1971","relationship":"same-class"},{"drugId":"budesonide","brandName":"budesonide","genericName":"budesonide","approvalYear":"1994","relationship":"same-class"},{"drugId":"diflorasone-diacetate","brandName":"diflorasone diacetate","genericName":"diflorasone diacetate","approvalYear":"1977","relationship":"same-class"},{"drugId":"amcinonide","brandName":"amcinonide","genericName":"amcinonide","approvalYear":"1979","relationship":"same-class"},{"drugId":"mometasone-furoate","brandName":"mometasone furoate","genericName":"mometasone furoate","approvalYear":"1987","relationship":"same-class"},{"drugId":"beclometasone-dipropionate","brandName":"beclometasone dipropionate","genericName":"beclometasone dipropionate","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03788863","phase":"","title":"A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2018-11-16","conditions":["Relationship Between the Exposure of Glucocorticoids During Pregnancy and Orofacial Cleft Development"],"enrollment":99999,"completionDate":"2018-11-29"},{"nctId":"NCT02627989","phase":"","title":"An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-12-10","conditions":["Dermatitis, Atopic"],"enrollment":55,"completionDate":"2017-01-17"},{"nctId":"NCT01098760","phase":"PHASE4","title":"Hepatocellular Carcinoma - Advanced Stage - Sorafenib Trial in Taiwanese Patients","status":"COMPLETED","sponsor":"Bayer","startDate":"2010-08","conditions":["Hepatocellular Carcinoma"],"enrollment":151,"completionDate":"2013-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167460","NDDF":"003782","UNII":"K253365DXI","CHEBI":"CHEBI:135624","INN_ID":"2395","RXNORM":"3392","UMLSCUI":"C0012227","ChEMBL_ID":"CHEMBL509924","KEGG_DRUG":"D03812","DRUGBANK_ID":"DB09095","PUBCHEM_CID":"11954369","SNOMEDCT_US":"116581007","MESH_DESCRIPTOR_UI":"D004060"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":106,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AC06","allCodes":["D07AC06","D07BC04","D07XC04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41709500","title":"Investigating the Telomerase Downregulatory Potential of Steroidal Drugs Following Pharmacophore-Based Rational; Computational and In Vitro Assessments.","journal":"Archiv der Pharmazie"},{"date":"2024 Sep","pmid":"39198945","title":"[Simultaneous determination of 61 hormones in water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry].","journal":"Se pu = Chinese journal of chromatography"},{"date":"2024 Sep 18","pmid":"38501938","title":"Efficacy and safety of topical corticosteroid treatment under occlusion for severe alopecia areata in children: a single-centre retrospective analysis.","journal":"Clinical and experimental dermatology"},{"date":"2023 Apr 25","pmid":"36788666","title":"Betamethasone cream to treat diapers rash causing Cushing syndrome.","journal":"Journal of pediatric endocrinology & metabolism : JPEM"},{"date":"2020","pmid":"33554496","title":"Cushing syndrome induced by long term use of corticosteroids in the management of atopic dermatitis.","journal":"Pediatric endocrinology, diabetes, and metabolism"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Difluocortolone is a small molecule corticosteroid drug of the diflucortolone class. Its exact target and mechanism of action are unknown, but it is believed to work by mimicking the effects of cortisol in the body, reducing inflammation and suppressing the immune system. Difluocortolone is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are also unknown. As a result, there is limited information available on its safety profile and potential side effects. Further research is needed to fully understand the properties and potential uses of difluocortolone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}