{"id":"diflucan-fluconazole","safety":{"commonSideEffects":[{"rate":"13","effect":"Headache"},{"rate":"7","effect":"Nausea"},{"rate":"6","effect":"Abdominal pain"},{"rate":"5","effect":"Diarrhea"},{"rate":"2","effect":"Rash"},{"rate":"1-3","effect":"Elevated liver enzymes"},{"rate":"<0.1","effect":"Stevens-Johnson syndrome"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By blocking the conversion of lanosterol to ergosterol, a critical sterol in fungal cell membranes, fluconazole causes membrane destabilization and leakage of cellular contents, leading to fungal cell death. This mechanism is selective for fungal cells because they rely on ergosterol, whereas human cells use cholesterol instead. Fluconazole is a triazole antifungal that acts as a fungistatic agent, halting fungal growth and allowing the immune system to clear the infection.","oneSentence":"Fluconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis and compromising fungal cell membrane integrity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:27.653Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Candidiasis (oropharyngeal, esophageal, vaginal, and systemic)"},{"name":"Cryptococcal meningitis"},{"name":"Coccidioidomycosis"},{"name":"Onychomycosis"},{"name":"Pityriasis versicolor"},{"name":"Fungal prophylaxis in immunocompromised patients"}]},"trialDetails":[{"nctId":"NCT04988555","phase":"PHASE1, PHASE2","title":"A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)","status":"RECRUITING","sponsor":"Sumitomo Pharma America, 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