{"id":"differin-0-1-adapalene-gel","safety":{"commonSideEffects":["Skin dryness","Erythema (redness)","Scaling/peeling","Burning or stinging sensation","Pruritus (itching)"],"contraindications":["Hypersensitivity to adapalene or any component of the formulation"]},"_chembl":{"chemblId":"CHEMBL1265","moleculeType":"Small molecule","molecularWeight":"412.53"},"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"Retinoic acid receptor gamma (RAR-γ) and retinoic acid receptor beta (RAR-β)","explanation":"Adapalene is a third-generation retinoid that selectively binds to nuclear retinoic acid receptors, particularly RAR-β and RAR-γ. This binding modulates cellular differentiation, keratinization, and inflammatory processes, preventing the formation of comedones and reducing acne lesions.","oneSentence":"Adapalene binds to specific retinoic acid receptors in skin cells to normalize keratinization and reduce inflammatory responses."},"_scrapedAt":"2026-03-28T05:02:18.564Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123407,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"tretinoin","brand":"Retin-A","company":"Johnson & Johnson","rationale":"First-generation topical retinoid for acne treatment"},{"name":"tazarotene","brand":"Tazorac","company":"Allergan","rationale":"Third-generation topical retinoid for acne and psoriasis"},{"name":"benzoyl peroxide","brand":null,"company":null,"rationale":"Alternative topical acne treatment with antibacterial properties"}],"description":"Differin (adapalene) 0.1% gel is a topical retinoid medication used primarily for the treatment of acne vulgaris. Developed by Stiefel, now part of GSK, adapalene works by modulating skin cell turnover and reducing inflammation in acne-prone skin.","indications":{"approved":[{"status":"approved","condition":"Acne vulgaris","patientPopulation":"Adults and adolescents aged 12 years and older"}]},"trialDetails":[{"nctId":"NCT00719121","phase":"PHASE1","title":"Study on Anti-inflammatory Effects of Topical R115866 Gel","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2006-11","conditions":"Cutaneous Inflammation","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":93,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["adapalene gel"],"phase":"phase_1","status":"active","brandName":"Differin™, 0.1% adapalene gel","genericName":"Differin™, 0.1% adapalene gel","companyName":"Stiefel, a GSK Company","companyId":"stiefel-a-gsk-company","firstApprovalDate":"","aiSummary":"Differin 0.1% adapalene gel is a topical medication that belongs to the class of small molecule retinoic acid receptor agonists. It is used to treat cutaneous inflammation, as indicated by clinical trials.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}