{"id":"different-doses-of-metoprolol","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"1-5","effect":"Bronchospasm"},{"rate":"5-10","effect":"Sexual dysfunction"},{"rate":"3-5","effect":"Insomnia"}]},"_chembl":{"chemblId":"CHEMBL2356097","moleculeType":"Small molecule","molecularWeight":"652.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metoprolol competitively blocks beta-1 adrenergic receptors on cardiac tissue, reducing the effects of catecholamines (epinephrine and norepinephrine). This leads to decreased heart rate, reduced contractility, and lower blood pressure. It is cardioselective at lower doses but can block beta-2 receptors at higher doses.","oneSentence":"Metoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate, blood pressure, and cardiac workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:35:15.069Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Acute myocardial infarction"},{"name":"Heart failure"},{"name":"Arrhythmias"},{"name":"Migraine prophylaxis"}]},"trialDetails":[{"nctId":"NCT07268170","phase":"PHASE2, PHASE3","title":"Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease","status":"ENROLLING_BY_INVITATION","sponsor":"Gødstrup Hospital","startDate":"2025-12-15","conditions":"Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD)","enrollment":350},{"nctId":"NCT06825728","phase":"PHASE4","title":"Metoprolol in Patients With HFrEF and COPD","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2025-02","conditions":"Heart Failure With Reduced Ejection Fraction (HFrEF), COPD (Chronic Obstructive Pulmonary Disease)","enrollment":311},{"nctId":"NCT05546320","phase":"PHASE4","title":"Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale","status":"UNKNOWN","sponsor":"Chinese Academy of Medical Sciences, Fuwai Hospital","startDate":"2022-10-15","conditions":"Patent Foramen Ovale, Migraine","enrollment":1000},{"nctId":"NCT02391337","phase":"PHASE4","title":"Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)","status":"COMPLETED","sponsor":"University of Birmingham","startDate":"2016-12-20","conditions":"Permanent Atrial Fibrillation","enrollment":161},{"nctId":"NCT04221919","phase":"NA","title":"Different β -Blockers in STEMI and Primary PCI","status":"UNKNOWN","sponsor":"Qilu Hospital of Shandong University","startDate":"2020-01","conditions":"Primary PCI","enrollment":1200},{"nctId":"NCT02336607","phase":"NA","title":"The Effects on Blood Pressure Control, Pulse Wave Velocity, as Well as Safety and Tolerability of Felodipine Sustained Release in Chinese Patients.","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2005-12","conditions":"Hypertension","enrollment":529},{"nctId":"NCT00578617","phase":"NA","title":"Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2006-09","conditions":"Atrial Fibrillation, Arrhythmia","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Different doses of Metoprolol.","genericName":"Different doses of Metoprolol.","companyName":"Xiangya Hospital of Central South University","companyId":"xiangya-hospital-of-central-south-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate, blood pressure, and cardiac workload. Used for Hypertension, Angina pectoris, Acute myocardial infarction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}