{"id":"difenpiramide","rwe":[{"pmid":"7160146","year":"1982","title":"[Evaluation of the therapeutic activity and tolerability of difenpiramide in otorhinolaryngology].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"},{"pmid":"7094545","year":"1982","title":"[Clinical study of difenpiramide in the treatment of degenerative and inflammatory arthropathies].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"},{"pmid":"7312201","year":"1981","title":"[Clinical aspects and microcirculation findings in the treatment of arthrotic arthropathies with difenpiramide].","finding":"","journal":"Minerva medica","studyType":"Clinical Study"},{"pmid":"7249571","year":"1981","title":"[The use of difenpiramide in local or circumscribed inflammation in obstetrics and gynecology].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"},{"pmid":"552255","year":"1979","title":"Physicochemical profile of a new antiinflammatory drug: difenpiramide.","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"}],"tags":[{"label":"difenpiramide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AB12","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diphenpyramide","offLabel":[],"synonyms":["difenpiramide","diphenpyramide","difenpiramide sulfate","difenpiramide maleate","difenpiramide monohydrochloride","difenpiramide hydrochloride","difenpiramide HCl"],"timeline":[],"approvals":[],"brandName":"Diphenpyramide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"difenpiramide","explanation":"Imagine your gut is like a muscle that can get crampy and inflamed. Diphenpyramide helps by blocking the signals that tell the muscle to contract and get inflamed, which can help relieve symptoms like cramps and diarrhea.","oneSentence":"Diphenpyramide works by blocking certain receptors in the gut to reduce spasms and inflammation.","technicalDetail":"Diphenpyramide is a competitive antagonist of the M1 muscarinic acetylcholine receptor, which plays a role in regulating gut motility and secretions."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/919","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=difenpiramide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:35:51.265466","biosimilars":[],"competitors":[{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sulindac","drugSlug":"sulindac","fdaApproval":"1978-09-27","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"etodolac","drugSlug":"etodolac","fdaApproval":"1991-01-31","genericCount":25,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketorolac","drugSlug":"ketorolac","fdaApproval":"1989-11-30","patentExpiry":"Nov 24, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"genericName":"difenpiramide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-class"},{"drugId":"sulindac","brandName":"sulindac","genericName":"sulindac","approvalYear":"1978","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"etodolac","brandName":"etodolac","genericName":"etodolac","approvalYear":"1991","relationship":"same-class"},{"drugId":"ketorolac","brandName":"ketorolac","genericName":"ketorolac","approvalYear":"1989","relationship":"same-class"},{"drugId":"aceclofenac","brandName":"aceclofenac","genericName":"aceclofenac","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Q6U5F6E1QL","CHEBI":"CHEBI:76130","UMLSCUI":"C0057982","ChEMBL_ID":"CHEMBL1489662","DRUGBANK_ID":"DB13371","PUBCHEM_CID":"100472","MESH_SUPPLEMENTAL_RECORD_UI":"C015136"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AB12","allCodes":["M01AB12"]},"biosimilarFilings":[],"recentPublications":[{"date":"1982 Dec 31","pmid":"7160146","title":"[Evaluation of the therapeutic activity and tolerability of difenpiramide in otorhinolaryngology].","journal":"La Clinica terapeutica"},{"date":"1982 Apr 30","pmid":"7094545","title":"[Clinical study of difenpiramide in the treatment of degenerative and inflammatory arthropathies].","journal":"La Clinica terapeutica"},{"date":"1981 Nov 14","pmid":"7312201","title":"[Clinical aspects and microcirculation findings in the treatment of arthrotic arthropathies with difenpiramide].","journal":"Minerva medica"},{"date":"1981 Jul 15","pmid":"7249571","title":"[The use of difenpiramide in local or circumscribed inflammation in obstetrics and gynecology].","journal":"La Clinica terapeutica"},{"date":"1979 Dec","pmid":"552255","title":"Physicochemical profile of a new antiinflammatory drug: difenpiramide.","journal":"Bollettino chimico farmaceutico"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diphenpyramide is a small molecule non-steroidal anti-inflammatory drug. It is also known by other names, including Difenax, Difenpiramide, and NSC-305337.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}