{"id":"difebarbamate","rwe":[{"pmid":"11824432","year":"2001","title":"Severe hepatitis due to Atrium.","finding":"","journal":"Prescrire international","studyType":"Clinical Study"},{"pmid":"7761807","year":"1995","title":"[Acute liver failure following tetrabamate].","finding":"","journal":"Schweizerische medizinische Wochenschrift","studyType":"Clinical Study"},{"pmid":"7699230","year":"1994","title":"Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"},{"pmid":"2253648","year":"1990","title":"Metabolism of difebarbamate in man.","finding":"","journal":"European journal of drug metabolism and pharmacokinetics","studyType":"Clinical Study"},{"pmid":"583248","year":"1979","title":"Comparative study of the inductive effect of two psychomoderators--tetrabamate and complexe 1656--and of phenobarbital on liver microsomal enzymes in rats.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"difebarbamate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["difebarbamate"],"offLabel":[],"synonyms":["difebarbamate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"difebarbamate","explanation":"Imagine your body's cells are like a orchestra, and difebarbamate is like a conductor that helps the different cells work together in harmony. By influencing the activity of specific enzymes or receptors, difebarbamate may help to regulate various bodily functions. However, the exact details of how it works are still unclear.","oneSentence":"Difebarbamate is thought to work by modulating the activity of certain enzymes or receptors in the body.","technicalDetail":"Difebarbamate is a small molecule that binds to and modulates the activity of specific enzymes or receptors, potentially influencing various signaling pathways and cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/876","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIFEBARBAMATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:41:34.813274","biosimilars":[],"competitors":[],"genericName":"difebarbamate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005324","UNII":"7EE4K616KK","INN_ID":"1240","RXNORM":"23020","UMLSCUI":"C0057977","ChEMBL_ID":"CHEMBL2105563","PUBCHEM_CID":"71880","MESH_SUPPLEMENTAL_RECORD_UI":"C007383"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2001 Oct","pmid":"11824432","title":"Severe hepatitis due to Atrium.","journal":"Prescrire international"},{"date":"1995 May 13","pmid":"7761807","title":"[Acute liver failure following tetrabamate].","journal":"Schweizerische medizinische Wochenschrift"},{"date":"1994 Dec","pmid":"7699230","title":"Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.","journal":"Journal of hepatology"},{"date":"1990 Jul-Sep","pmid":"2253648","title":"Metabolism of difebarbamate in man.","journal":"European journal of drug metabolism and pharmacokinetics"},{"date":"1979","pmid":"583248","title":"Comparative study of the inductive effect of two psychomoderators--tetrabamate and complexe 1656--and of phenobarbital on liver microsomal enzymes in rats.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"DIFEBARBAMATE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Difebarbamate is a small molecule drug in the difebarbamate class, but its target and exact mechanism of action are unknown. It is not clear if it is FDA-approved or commercially available. There is limited information available on its pharmacokinetic properties, such as half-life and bioavailability. Further research is needed to understand its clinical applications and safety profile. As a result, it is difficult to provide a comprehensive summary of this drug.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}