{"id":"diethylcarbamazine-on-day-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Allergic reactions (due to parasite death)"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diethylcarbamazine (DEC) is a microfilaricide that acts on the nervous system of microfilariae, causing paralysis and death. It enhances the host immune response against the parasites, facilitating their removal by macrophages and other immune cells. The drug is particularly effective against Wuchereria bancrofti, Brugia malayi, and Loa loa microfilariae.","oneSentence":"Diethylcarbamazine immobilizes and kills microfilariae by interfering with their neuromuscular function, making them susceptible to immune clearance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:53.138Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lymphatic filariasis (Wuchereria bancrofti, Brugia malayi infection)"},{"name":"Loiasis (Loa loa infection)"},{"name":"Onchocerciasis (as adjunctive therapy)"}]},"trialDetails":[{"nctId":"NCT03177993","phase":"NA","title":"Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-07-13","conditions":"Lymphatic Filariases, Scabies, Impetigo","enrollment":4773},{"nctId":"NCT03676140","phase":"PHASE3","title":"Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )","status":"COMPLETED","sponsor":"Lihir Medical Centre","startDate":"2018-10-01","conditions":"Trachoma, Yaws, Lymphatic Filariases","enrollment":20000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DEC-d1","Banocide"],"phase":"phase_3","status":"active","brandName":"Diethylcarbamazine on day 1","genericName":"Diethylcarbamazine on day 1","companyName":"Lihir Medical Centre","companyId":"lihir-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diethylcarbamazine immobilizes and kills microfilariae by interfering with their neuromuscular function, making them susceptible to immune clearance. Used for Lymphatic filariasis (Wuchereria bancrofti, Brugia malayi infection), Loiasis (Loa loa infection), Onchocerciasis (as adjunctive therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}