{"id":"diethylaminoethoxyhexestrol","rwe":[{"pmid":"26436351","year":"2015","title":"Drug-induced fatty liver disease: An overview of pathogenesis and management.","finding":"","journal":"Annals of hepatology","studyType":"Clinical Study"},{"pmid":"22828012","year":"2012","title":"Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.","finding":"","journal":"Toxicology letters","studyType":"Clinical Study"},{"pmid":"18603402","year":"2008","title":"Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.","finding":"","journal":"Toxicology in vitro : an international journal published in association with BIBRA","studyType":"Clinical Study"},{"pmid":"9516397","year":"1998","title":"Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.","finding":"","journal":"Gastroenterology","studyType":"Clinical Study"},{"pmid":"9204409","year":"1997","title":"Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"}],"tags":[{"label":"diethylaminoethoxyhexestrol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["diethylaminoethoxyhexestrol"],"offLabel":[],"synonyms":["diethylaminoethoxyhexestrol"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"diethylaminoethoxyhexestrol","explanation":"Imagine your body's cells have locks on them, and diethylaminoethoxyhexestrol is a key that fits into those locks. When it binds to the receptors, it can either activate or block the normal function of the cell, depending on the type of receptor and the specific effects of the compound. This can lead to changes in how the cell behaves and responds to signals.","oneSentence":"Diethylaminoethoxyhexestrol is a small molecule that works by binding to specific receptors in the body.","technicalDetail":"Diethylaminoethoxyhexestrol is a nonsteroidal estrogen agonist that exerts its effects through binding to estrogen receptors, potentially influencing gene expression and cellular function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3276","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diethylaminoethoxyhexestrol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:35:23.078478","biosimilars":[],"competitors":[],"genericName":"diethylaminoethoxyhexestrol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"UBR09A3IFF","UMLSCUI":"C0062669","PUBCHEM_CID":"66143"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":35,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2015 Nov-Dec","pmid":"26436351","title":"Drug-induced fatty liver disease: An overview of pathogenesis and management.","journal":"Annals of hepatology"},{"date":"2012 Sep 3","pmid":"22828012","title":"Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.","journal":"Toxicology letters"},{"date":"2008 Sep","pmid":"18603402","title":"Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.","journal":"Toxicology in vitro : an international journal published in association with BIBRA"},{"date":"1998 Apr","pmid":"9516397","title":"Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.","journal":"Gastroenterology"},{"date":"1997","pmid":"9204409","title":"Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines.","journal":"Journal of hepatology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"diethylaminoethoxyhexestrol","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diethylaminoethoxyhexestrol is a small molecule drug of the diethylaminoethoxyhexestrol class, but limited information is available on its development, commercial status, and clinical use. It is unclear who originally developed the compound or its current owner, and it has not been approved by the FDA for any indications. As a result, there is no information available on its half-life, bioavailability, or generic manufacturers. Further research is needed to determine the target, mechanism of action, and safety profile of diethylaminoethoxyhexestrol. Its commercial status is also unknown, making it difficult to determine if it is patented or available as a generic.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}