{"id":"diethyl-ether","rwe":[{"pmid":"41901446","year":"2026","title":"Species-Specific Metabolite Profiles and Biological Activities of Bulgarian Thymus Species from Section Hyphodromi.","finding":"","journal":"Plants (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41862605","year":"2026","title":"Photothermal solar assisted Madhuca diethyl ether fuel processing for LHR engines with AI-based performance and yield prediction.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41853205","year":"2026","title":"Sustainable catalytic conversion of ethanol: catalyst design and modification strategies for dehydration and petrochemical applications.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41832314","year":"2026","title":"Performance and combustion characteristics of an HCCI engine fueled with n‑Butanol/diethyl ether blends under varying intake‑air temperatures.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41720820","year":"2026","title":"Detecting glycosyl-oxonium and glycosyl-nitrilium ions using exchange NMR to investigate solvent effects in glycosylation reactions.","finding":"","journal":"Nature communications","studyType":"Clinical Study"}],"tags":[{"label":"diethyl ether","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N01AA01","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ethoxyethane","offLabel":[],"synonyms":["diethyl ether","ethoxyethane"],"timeline":[],"approvals":[],"brandName":"Ethoxyethane","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"diethyl ether","explanation":"When diethyl ether is inhaled or ingested, it quickly enters the bloodstream and crosses the blood-brain barrier, where it binds to receptors in the brain and spinal cord, leading to a loss of consciousness and sensation. This results in a state of general anesthesia, characterized by immobility, amnesia, and a lack of pain perception. Diethyl ether's mechanism of action is complex and not fully understood, but it is thought to involve the modulation of neurotransmitter release and the activation of GABA receptors.","oneSentence":"Diethyl ether works by inducing general anesthesia through its effects on the central nervous system.","technicalDetail":"Diethyl ether's mechanism of action is thought to involve the inhibition of the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine in the synaptic cleft and a subsequent activation of nicotinic and muscarinic receptors. This results in a depolarization of neurons and a subsequent loss of consciousness. Additionally, diethyl ether may also interact with other neurotransmitter systems, including the GABA and glutamate systems, to produce its anesthetic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4417","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=diethyl%20ether","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diethyl ether","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:35:18.143083","biosimilars":[],"competitors":[],"genericName":"diethyl ether","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03678350","phase":"PHASE1","title":"Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"2021-09-17","conditions":["Malignant Mesothelioma","Non-Small Cell Lung Carcinoma","Pleural Disorder"],"enrollment":9,"completionDate":"2025-10-09"},{"nctId":"NCT06565988","phase":"NA","title":"A Post-market-clinical Follow-up Investigation of Safety and Performance by Decoria® Voluma","status":"COMPLETED","sponsor":"Bohus Biotech AB","startDate":"2024-09-02","conditions":["Midface Volume Deficit"],"enrollment":111,"completionDate":"2025-09-26"},{"nctId":"NCT02858310","phase":"PHASE1,PHASE2","title":"E7 TCR T Cells for Human Papillomavirus-Associated Cancers","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-27","conditions":["Papillomavirus Infections","Cervical Intraepithelial Neoplasia","Carcinoma In Situ","Vulvar Neoplasms","Vulvar Diseases"],"enrollment":224,"completionDate":"2025-07-02"},{"nctId":"NCT05583864","phase":"NA","title":"Lumbar Fusion With Porous Versus Non-Porous Cages","status":"ACTIVE_NOT_RECRUITING","sponsor":"Francis Farhadi","startDate":"2022-11-01","conditions":["Spinal Fusion","Lumbar Fusion","Arthrodesis","Spondylolisthesis","Pseudarthrosis"],"enrollment":108,"completionDate":"2027-06"},{"nctId":"NCT04836429","phase":"PHASE1","title":"Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease","status":"TERMINATED","sponsor":"Roswell Park Cancer Institute","startDate":"2022-03-10","conditions":["Lung Non-Small Cell Carcinoma","Pleural Disorder"],"enrollment":5,"completionDate":"2025-01-03"},{"nctId":"NCT04630626","phase":"NA","title":"Post-Approval Study Protocol for the Simplify Cervical Artificial Disc","status":"COMPLETED","sponsor":"NuVasive","startDate":"2021-01-01","conditions":["Cervical Degenerative Disc Disorder"],"enrollment":145,"completionDate":"2023-04-23"},{"nctId":"NCT04980378","phase":"","title":"Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc","status":"COMPLETED","sponsor":"NuVasive","startDate":"2021-08-01","conditions":["Cervical Degenerative Disc Disorder"],"enrollment":291,"completionDate":"2024-01-24"},{"nctId":"NCT02153229","phase":"PHASE2","title":"Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2014-06-02","conditions":["Epitheliod Malignant Pleural Mesothelioma"],"enrollment":52,"completionDate":"2027-12"},{"nctId":"NCT06731244","phase":"NA","title":"Shared Decision-making Process for Unprovoked vEnous THromboEmbolism Management. 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