{"id":"diethazine","rwe":[{"pmid":"14751789","year":"2004","title":"Urine sample preparation of tricyclic antidepressants by means of a supported liquid membrane technique for high-performance liquid chromatographic analysis.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"9137772","year":"1997","title":"Spectrofluorimetric determination of diethazine and promethazine in pharmaceutical preparations.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"},{"pmid":"18965303","year":"1991","title":"Effects of salts on the stability of the cationic radical of phenothiazine derivatives.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"3047509","year":"1988","title":"Antiplasmid activity of tricyclic compounds.","finding":"","journal":"Methods and findings in experimental and clinical pharmacology","studyType":"Clinical Study"},{"pmid":"2845051","year":"1988","title":"Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dolisina","offLabel":[],"synonyms":["diethazine","dolisina","eazamine","eazaminum","parkazin"],"timeline":[],"approvals":[],"brandName":"Dolisina","ecosystem":[],"mechanism":{"target":"Pleiotropic ABC efflux transporter of multiple drugs","modality":"Small Molecule","explanation":"While the exact details of how Dolisina works are not well understood, it is believed to affect the brain's chemistry to produce a calming effect. This can help to reduce anxiety and other symptoms associated with certain conditions. However, more research is needed to fully understand its mechanism of action.","oneSentence":"Dolisina is thought to work by interacting with a specific target in the body to produce a therapeutic effect.","technicalDetail":"Dolisina's mechanism of action is not well characterized, but it is thought to interact with a specific target in the brain to produce a therapeutic effect. This may involve modulation of neurotransmitter systems, such as GABA or serotonin, although this has not been confirmed."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/872","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIETHAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:41:00.809598","biosimilars":[],"competitors":[{"drugName":"chlorpromazine","drugSlug":"chlorpromazine","fdaApproval":"1957-09-18","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"chlorprothixene","drugSlug":"chlorprothixene","fdaApproval":"1967-06-19","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"fluphenazine","drugSlug":"fluphenazine","fdaApproval":"1959-09-09","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"imipramine","drugSlug":"imipramine","fdaApproval":"1959-04-16","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"levomepromazine","drugSlug":"levomepromazine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"perphenazine","drugSlug":"perphenazine","fdaApproval":"1957-02-27","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"prochlorperazine","drugSlug":"prochlorperazine","fdaApproval":"1956-10-23","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"promazine","drugSlug":"promazine","fdaApproval":"1956-04-13","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"thiethylperazine","drugSlug":"thiethylperazine","fdaApproval":"1961-07-18","patentStatus":"Unknown","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"diethazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chlorpromazine","brandName":"chlorpromazine","genericName":"chlorpromazine","approvalYear":"1957","relationship":"same-target"},{"drugId":"chlorprothixene","brandName":"chlorprothixene","genericName":"chlorprothixene","approvalYear":"1967","relationship":"same-target"},{"drugId":"fluphenazine","brandName":"fluphenazine","genericName":"fluphenazine","approvalYear":"1959","relationship":"same-target"},{"drugId":"imipramine","brandName":"imipramine","genericName":"imipramine","approvalYear":"1959","relationship":"same-target"},{"drugId":"levomepromazine","brandName":"levomepromazine","genericName":"levomepromazine","approvalYear":"","relationship":"same-target"},{"drugId":"perphenazine","brandName":"perphenazine","genericName":"perphenazine","approvalYear":"1957","relationship":"same-target"},{"drugId":"prochlorperazine","brandName":"prochlorperazine","genericName":"prochlorperazine","approvalYear":"1956","relationship":"same-target"},{"drugId":"promazine","brandName":"promazine","genericName":"promazine","approvalYear":"1956","relationship":"same-target"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-target"},{"drugId":"thiethylperazine","brandName":"thiethylperazine","genericName":"thiethylperazine","approvalYear":"1961","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"28B5CG0RU3","CHEBI":"CHEBI:135265","INN_ID":"1539","UMLSCUI":"C0057921","ChEMBL_ID":"CHEMBL1620412","KEGG_DRUG":"D07823","PUBCHEM_CID":"65535","MESH_SUPPLEMENTAL_RECORD_UI":"C100260"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":37,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2004 Mar 5","pmid":"14751789","title":"Urine sample preparation of tricyclic antidepressants by means of a supported liquid membrane technique for high-performance liquid chromatographic analysis.","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"date":"1997 Mar-Apr","pmid":"9137772","title":"Spectrofluorimetric determination of diethazine and promethazine in pharmaceutical preparations.","journal":"Biomedical chromatography : BMC"},{"date":"1991 Nov","pmid":"18965303","title":"Effects of salts on the stability of the cationic radical of phenothiazine derivatives.","journal":"Talanta"},{"date":"1988 Jul","pmid":"3047509","title":"Antiplasmid activity of tricyclic compounds.","journal":"Methods and findings in experimental and clinical pharmacology"},{"date":"1988 Jul","pmid":"2845051","title":"Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.","journal":"Journal of pharmaceutical sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dolisina is a small molecule with synonyms including DIETAZINA, DIETHAZINE, and DIETHAZINE. Its modality is classified as a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}