{"id":"diethadione","rwe":[{"pmid":"4381273","year":"1966","title":"[Inhibiting action of gamma-amino-butyrylcholine on convulsive crises and on electroencephalographic paroxysms evoked by diethadione, by hyperpnea and by intermittent light stimulation in epileptic subjects].","finding":"","journal":"Rivista di neurobiologia : organo ufficiale della Societa dei neurologi, neuroradiologi e neurochirurghi ospedalieri","studyType":"Clinical Study"},{"pmid":"14200510","year":"1964","title":"[INFLUENCE OF A RESPIRATORY ANALEPTIC, DIETHADIONE, ON VENTILATORY MECHANICAL WORK AFTER SODIUM PENTOTHAL INJECTION].","finding":"","journal":"Pathologie et biologie","studyType":"Clinical Study"},{"pmid":"14210398","year":"1964","title":"[ELECTROPHYSIOLOGICAL RESEARCH ON THE ACTION OF AN OXAZINE-DIONE DERIVATIVE (DIETHADIONE) ON THE RESPIRATORY CENTERS].","finding":"","journal":"Archivio di scienze biologiche","studyType":"Clinical Study"},{"pmid":"14154986","year":"1964","title":"[DIETHADIONE IN FLUOTHANE ANESTHESIA IN EXTRA-ABDOMINAL UROLOGICAL AND OPHTHALMIC SURGERY].","finding":"","journal":"Acta anaesthesiologica","studyType":"Clinical Study"},{"pmid":"14175172","year":"1964","title":"[INFLUENCE OF ORAL DIETHADIONE ADMINISTRATION ON THE HYPERCAPNIA OF THE CHRONIC PULMONARY PATIENT].","finding":"","journal":"Acta tuberculosea et pneumologica Belgica","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dioxone","offLabel":[],"synonyms":["dietroxine","diethadione","dietroxin","dioxone","ledosten","persisten"],"timeline":[],"approvals":[],"brandName":"Dioxone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine Dioxone as a key that fits into a lock on a specific protein. When it binds, it can either turn the protein on or off, or change the way it works, which can help to treat a particular disease or condition. This is a simplified explanation of how small molecules like Dioxone can work to produce a therapeutic effect.","oneSentence":"Dioxone is a small molecule that works by binding to specific biological molecules to produce a therapeutic effect.","technicalDetail":"Dioxone's exact mechanism of action is unknown, but as a small molecule, it is likely to work through a reversible binding interaction with a specific protein target, potentially altering its activity or expression to produce a therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3729","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DIETHADIONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:35:12.674300","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:50:55.660745+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"diethadione","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Z0SPD4Z01X","CHEBI":"CHEBI:134803","INN_ID":"1264","RXNORM":"1428867","UMLSCUI":"C2699766","ChEMBL_ID":"CHEMBL96868","PUBCHEM_CID":"12798"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1966 Apr-Jun","pmid":"4381273","title":"[Inhibiting action of gamma-amino-butyrylcholine on convulsive crises and on electroencephalographic paroxysms evoked by diethadione, by hyperpnea and by intermittent light stimulation in epileptic subjects].","journal":"Rivista di neurobiologia : organo ufficiale della Societa dei neurologi, neuroradiologi e neurochirurghi ospedalieri"},{"date":"1964 Aug-Sep","pmid":"14200510","title":"[INFLUENCE OF A RESPIRATORY ANALEPTIC, DIETHADIONE, ON VENTILATORY MECHANICAL WORK AFTER SODIUM PENTOTHAL INJECTION].","journal":"Pathologie et biologie"},{"date":"1964 Apr-Jun","pmid":"14210398","title":"[ELECTROPHYSIOLOGICAL RESEARCH ON THE ACTION OF AN OXAZINE-DIONE DERIVATIVE (DIETHADIONE) ON THE RESPIRATORY CENTERS].","journal":"Archivio di scienze biologiche"},{"date":"1964 Mar-Apr","pmid":"14154986","title":"[DIETHADIONE IN FLUOTHANE ANESTHESIA IN EXTRA-ABDOMINAL UROLOGICAL AND OPHTHALMIC SURGERY].","journal":"Acta anaesthesiologica"},{"date":"1964 Jan-Feb","pmid":"14175172","title":"[INFLUENCE OF ORAL DIETHADIONE ADMINISTRATION ON THE HYPERCAPNIA OF THE CHRONIC PULMONARY PATIENT].","journal":"Acta tuberculosea et pneumologica Belgica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dioxone, also known as Diethadione, is a small molecule compound with unknown target and drug class. Its commercial status is unclear, and it is not known whether it is FDA-approved or off-patent. As a small molecule, it is likely to work by interacting with specific biological molecules to produce a therapeutic effect. However, without more information, it is difficult to determine its exact mechanism of action or approved indications. Further research is needed to fully understand the properties and uses of Dioxone.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:50:55.660745+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}