{"id":"diclofenac-topical","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Application site reactions (erythema, pruritus, irritation)"},{"rate":"1-5","effect":"Contact dermatitis"},{"rate":"rare","effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":{"setId":"223f0fb4-2006-c2dd-e063-6394a90a563a","title":"DICLOFENAC SODIUM TOPICAL SOLUTION SOLUTION [DIRECT_RX]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When applied topically, diclofenac penetrates the skin and underlying tissues to inhibit both COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing local prostaglandin levels, topical diclofenac provides anti-inflammatory and analgesic effects with minimal systemic absorption compared to oral formulations. This localized action makes it suitable for treating pain and inflammation in superficial musculoskeletal conditions.","oneSentence":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of application.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:23.760Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of pain and inflammation associated with osteoarthritis"},{"name":"Topical treatment of acute musculoskeletal pain and strains"}]},"trialDetails":[{"nctId":"NCT07475663","phase":"PHASE3","title":"Counterpain PXM Versus Diclofenac Versus Piroxicam","status":"COMPLETED","sponsor":"Taisho Pharmaceutical Indonesia","startDate":"2025-11-04","conditions":"Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee","enrollment":180},{"nctId":"NCT07212647","phase":"NA","title":"Home-Based Strategies for Knee Osteoarthritis","status":"COMPLETED","sponsor":"Istanbul University - Cerrahpasa","startDate":"2025-10-09","conditions":"Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)","enrollment":83},{"nctId":"NCT07079969","phase":"PHASE2","title":"Effects of Photobiomodulation and Topical Diclofenac on Inflammation and Pain in Knee Osteoarthritis (EPIC-KO)","status":"NOT_YET_RECRUITING","sponsor":"University of Florida","startDate":"2026-04","conditions":"Knee Pain Chronic","enrollment":32},{"nctId":"NCT02636569","phase":"PHASE2","title":"Topical Chemoprevention of Skin Cancer Biomarkers","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2017-10-25","conditions":"Non-melanoma Skin Cancer","enrollment":24},{"nctId":"NCT06729073","phase":"PHASE1","title":"Comparison of Diclofenac Systemic Exposure From Two Different Products (AMZ001 and Diclofenac Diethylammonium 1.16% Gel) in Healthy Participants After Repeated Topical Administrations for 7 Days.","status":"COMPLETED","sponsor":"Amzell","startDate":"2024-11-29","conditions":"Healthy Volunteer","enrollment":34},{"nctId":"NCT04091022","phase":"PHASE2","title":"Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2021-01-18","conditions":"Non-melanoma Skin Cancer","enrollment":64},{"nctId":"NCT07060976","phase":"NA","title":"To Check Dermatological Safety of Test Products by 24 Hours Patch Testing","status":"COMPLETED","sponsor":"Novamed Laboratories Pvt. 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