{"id":"diclofenac-sodium-active-topical-patch-1","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Diclofenac Sodium works by inhibiting the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins, leading to pain relief and anti-inflammatory effects.","oneSentence":"Diclofenac Sodium is a non-selective COX-2 inhibitor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:32:47.421Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain relief"},{"name":"Inflammation"}]},"trialDetails":[{"nctId":"NCT03277066","phase":"PHASE2","title":"A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Noven Pharmaceuticals, Inc.","startDate":"2017-09-07","conditions":"Osteoarthritis of the Knee","enrollment":289},{"nctId":"NCT00869063","phase":"PHASE3","title":"Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion","status":"COMPLETED","sponsor":"Cerimon Pharmaceuticals","startDate":"2009-02","conditions":"Acute Pain","enrollment":214},{"nctId":"NCT00640705","phase":"PHASE2, PHASE3","title":"Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain","status":"TERMINATED","sponsor":"Cerimon Pharmaceuticals","startDate":"2008-01","conditions":"Ankle Sprain","enrollment":170},{"nctId":"NCT00640939","phase":"PHASE2, PHASE3","title":"Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis","status":"COMPLETED","sponsor":"Cerimon Pharmaceuticals","startDate":"2007-12","conditions":"Rotator Cuff Tendonitis, Bicipital Tendonitis, Subdeltoid Bursitis of the Shoulder","enrollment":308}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["HP-5000"],"phase":"phase_2","status":"active","brandName":"Diclofenac Sodium Active Topical Patch 1","genericName":"Diclofenac Sodium Active Topical Patch 1","companyName":"Noven Pharmaceuticals, Inc.","companyId":"noven-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac Sodium Active Topical Patch 1 is used to treat conditions such as rotator cuff tendonitis, bicipital tendonitis, subdeltoid bursitis of the shoulder, subacromial bursitis of the shoulder, and medial epicondylitis of the elbow. It works by inhibiting cyclooxygenase, an enzyme involved in the production of prostaglandins, which are associated with pain and inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}