{"id":"diclofenac-oral-scopolamina-oral","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset (reduced vs. diclofenac alone)"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, providing analgesic and anti-inflammatory effects. Scopolamine is an anticholinergic agent that blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing motility, secretions, and associated nausea—effects that help mitigate NSAID-induced GI side effects.","oneSentence":"This combination uses diclofenac to reduce pain and inflammation via COX inhibition, and scopolamine to reduce gastrointestinal motility and secretions, thereby decreasing nausea and cramping associated with the NSAID.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:42.743Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain with associated nausea or gastrointestinal cramping"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT03506763","phase":"PHASE4","title":"Effect of Pre-medication in Pain Measures on Office Hysteroscopy","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2017-08-01","conditions":"Pain","enrollment":231}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diclofenac 50 mg oral tablet, scopolamin 10 mg oral tablet"],"phase":"marketed","status":"active","brandName":"Diclofenac oral + scopolamina oral","genericName":"Diclofenac oral + scopolamina oral","companyName":"Hospital de Clinicas de Porto Alegre","companyId":"hospital-de-clinicas-de-porto-alegre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses diclofenac to reduce pain and inflammation via COX inhibition, and scopolamine to reduce gastrointestinal motility and secretions, thereby decreasing nausea and cramping associated with the NSAID. Used for Acute pain with associated nausea or gastrointestinal cramping, Postoperative pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}