{"id":"diclofenac-diethylamine-ddea-2-32-gel","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"},{"rate":"null","effect":"Renal impairment"},{"rate":"null","effect":"Hypersensitivity reactions"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, an enzyme responsible for the production of prostaglandins, which are mediators of inflammation and pain. By inhibiting COX-2, diclofenac diethylamine reduces the production of prostaglandins, leading to a decrease in inflammation and pain. This mechanism of action is responsible for its analgesic, anti-inflammatory, and antipyretic effects.","oneSentence":"Diclofenac diethylamine works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:22.630Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of osteoarthritis"},{"name":"Treatment of rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT04052620","phase":"PHASE3","title":"Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-10-24","conditions":"Pain","enrollment":313},{"nctId":"NCT03497039","phase":"PHASE1","title":"A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2018-07-19","conditions":"Pain","enrollment":47},{"nctId":"NCT01967550","phase":"PHASE3","title":"Efficacy and Safety of Diclofenac DDEA 2.32 % in Patient Suffering From Knee Osteoarthritis (OA)","status":"COMPLETED","sponsor":"Novartis","startDate":"2013-10","conditions":"Osteoarthritis, Knee","enrollment":304}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"diclofenac diethylamine, DDEA 2.32% gel","genericName":"diclofenac diethylamine, DDEA 2.32% gel","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac diethylamine works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain. Used for Treatment of osteoarthritis, Treatment of rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}