{"id":"diclofenac-diethylamine-1-16-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash at application site"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. When applied topically as a gel, it penetrates the skin to reach underlying tissues and joints, providing localized anti-inflammatory and analgesic effects with reduced systemic exposure compared to oral formulations.","oneSentence":"Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of application.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:38.250Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of pain and inflammation associated with osteoarthritis and other joint conditions"},{"name":"Localized musculoskeletal pain and inflammation"}]},"trialDetails":[{"nctId":"NCT06729073","phase":"PHASE1","title":"Comparison of Diclofenac Systemic Exposure From Two Different Products (AMZ001 and Diclofenac Diethylammonium 1.16% Gel) in Healthy Participants After Repeated Topical Administrations for 7 Days.","status":"COMPLETED","sponsor":"Amzell","startDate":"2024-11-29","conditions":"Healthy Volunteer","enrollment":34},{"nctId":"NCT04052620","phase":"PHASE3","title":"Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-10-24","conditions":"Pain","enrollment":313},{"nctId":"NCT01335724","phase":"PHASE4","title":"Efficacy and Safety of Diclofenac 1.16% Gel in Subjects With Acute Neck Pain","status":"COMPLETED","sponsor":"Novartis","startDate":"2011-04","conditions":"Neck Pain","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Diclofenac diethylamine 1.16% gel","genericName":"Diclofenac diethylamine 1.16% gel","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of application. Used for Topical treatment of pain and inflammation associated with osteoarthritis and other joint conditions, Localized musculoskeletal pain and inflammation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}