{"id":"diclofenac-diethylamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash or skin irritation (topical formulations)"},{"rate":null,"effect":"Increased cardiovascular risk (with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac diethylamine is a salt formulation of diclofenac designed for topical or systemic delivery. It works by inhibiting both COX-1 and COX-2 enzymes, which catalyze prostaglandin production. By reducing prostaglandins, the drug decreases inflammatory mediators and provides analgesic and anti-inflammatory effects. The diethylamine salt form may enhance absorption and bioavailability compared to the base diclofenac.","oneSentence":"Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:26.135Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain and inflammation"},{"name":"Musculoskeletal pain and inflammation"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT06729073","phase":"PHASE1","title":"Comparison of Diclofenac Systemic Exposure From Two Different Products (AMZ001 and Diclofenac Diethylammonium 1.16% Gel) in Healthy Participants After Repeated Topical Administrations for 7 Days.","status":"COMPLETED","sponsor":"Amzell","startDate":"2024-11-29","conditions":"Healthy Volunteer","enrollment":34},{"nctId":"NCT07060976","phase":"NA","title":"To Check Dermatological Safety of Test Products by 24 Hours Patch Testing","status":"COMPLETED","sponsor":"Novamed Laboratories Pvt. 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Used for Acute pain and inflammation, Musculoskeletal pain and inflammation, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}