{"id":"diclofenac-cream-8","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash at application site"},{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac cream penetrates the skin to reach underlying tissues where it blocks COX-1 and COX-2 enzymes, reducing the production of inflammatory prostaglandins. This localized anti-inflammatory and analgesic effect provides pain relief and reduces swelling without the systemic exposure associated with oral NSAIDs. The 8% formulation delivers a higher concentration of the active ingredient to the affected area.","oneSentence":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:22.437Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of localized pain and inflammation associated with osteoarthritis and other musculoskeletal conditions"},{"name":"Acute pain relief from minor sprains, strains, and contusions"}]},"trialDetails":[{"nctId":"NCT04534426","phase":"PHASE4","title":"Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus","status":"COMPLETED","sponsor":"Abant Izzet Baysal University","startDate":"2018-12-01","conditions":"Impacted Third Molar Tooth","enrollment":60},{"nctId":"NCT02068859","phase":"PHASE3","title":"Treatment of Knee Pain With Topical Diclofenac Cream 8% or Diclofenac Gel 1%","status":"UNKNOWN","sponsor":"FPR Specialty Pharmacy","startDate":"2014-01","conditions":"Knee Pain Chronic, Knee Injuries","enrollment":106}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Diclofenac Cream 8%","genericName":"Diclofenac Cream 8%","companyName":"FPR Specialty Pharmacy","companyId":"fpr-specialty-pharmacy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application. Used for Topical treatment of localized pain and inflammation associated with osteoarthritis and other musculoskeletal conditions, Acute pain relief from minor sprains, strains, and contusions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}