{"id":"diclofenac-capsules-low-dose","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, an enzyme responsible for the production of prostaglandins, which are mediators of inflammation and pain. By inhibiting COX-2, diclofenac reduces the production of prostaglandins, leading to decreased inflammation and pain. This mechanism of action is responsible for the therapeutic effects of diclofenac in treating conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.","oneSentence":"Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:32:45.198Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis"},{"name":"Rheumatoid arthritis"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[{"nctId":"NCT00640432","phase":"PHASE4","title":"Safety And Efficacy Of Celecoxib Versus Sodium Diclofenac In The Treatment Of Acute Low Back Pain","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-10","conditions":"Low Back Pain","enrollment":244},{"nctId":"NCT02424578","phase":"PHASE2","title":"Study of Diclofenac Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age","status":"COMPLETED","sponsor":"Iroko Pharmaceuticals, LLC","startDate":"2015-05","conditions":"Pain, Postoperative","enrollment":30},{"nctId":"NCT01300312","phase":"PHASE3","title":"A Clinical Trial to Study the Effects of a Fixed Dose Combination of Diclofenac and Eperisone Hydrochloride With Plain Eperisone Hydrochloride in Patients With Low Back Pain","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Acute Musculoskeletal Spasm Due to Low Back Pain","enrollment":239}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Diclofenac Capsules low dose","genericName":"Diclofenac Capsules low dose","companyName":"Iroko Pharmaceuticals, LLC","companyId":"iroko-pharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain. Used for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}