{"id":"diclofenac-capsules-high-dose","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, an enzyme responsible for the production of prostaglandins, which are mediators of inflammation and pain. By inhibiting COX-2, diclofenac reduces the production of prostaglandins, leading to decreased inflammation and pain. This mechanism of action is responsible for the therapeutic effects of diclofenac in treating conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.","oneSentence":"Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:32:45.940Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis"},{"name":"Rheumatoid arthritis"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[{"nctId":"NCT02424578","phase":"PHASE2","title":"Study of Diclofenac Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age","status":"COMPLETED","sponsor":"Iroko Pharmaceuticals, LLC","startDate":"2015-05","conditions":"Pain, Postoperative","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Diclofenac Capsules high dose","genericName":"Diclofenac Capsules high dose","companyName":"Iroko Pharmaceuticals, LLC","companyId":"iroko-pharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain. Used for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}