{"id":"diclofenac-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Systemic NSAID-related gastrointestinal effects (with significant absorption)"}]},"_chembl":{"chemblId":"CHEMBL139","moleculeType":"Small molecule","molecularWeight":"296.15"},"_dailymed":{"setId":"a133d18e-981d-43b7-bef1-7869f7c7d9a7","title":"DICLOFENAC SODIUM (DICLOFENAC SODIUM TOPICAL GEL, 1%) GEL [SPORTPHARM LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac blocks both COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at the site of application (topical 1% formulation), it provides localized anti-inflammatory and analgesic effects with potentially lower systemic exposure compared to oral formulations.","oneSentence":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:48.439Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of localized pain and inflammation associated with osteoarthritis, musculoskeletal injuries, and other localized inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT07493226","phase":"NA","title":"Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","status":"RECRUITING","sponsor":"Konya Beyhekim Training and Research Hospital","startDate":"2026-04-01","conditions":"Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain","enrollment":120},{"nctId":"NCT07475663","phase":"PHASE3","title":"Counterpain PXM Versus Diclofenac Versus Piroxicam","status":"COMPLETED","sponsor":"Taisho Pharmaceutical Indonesia","startDate":"2025-11-04","conditions":"Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee","enrollment":180},{"nctId":"NCT06566794","phase":"NA","title":"KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2024-08-22","conditions":"Drug Interaction","enrollment":12},{"nctId":"NCT05761015","phase":"PHASE4","title":"Helping Osteoarthritis Patients to Walk With NSAID","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2023-12-14","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain","enrollment":55},{"nctId":"NCT07079969","phase":"PHASE2","title":"Effects of Photobiomodulation and Topical Diclofenac on Inflammation and Pain in Knee Osteoarthritis (EPIC-KO)","status":"NOT_YET_RECRUITING","sponsor":"University of Florida","startDate":"2026-04","conditions":"Knee Pain Chronic","enrollment":32},{"nctId":"NCT06731270","phase":"PHASE2","title":"Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy","status":"RECRUITING","sponsor":"Emory University","startDate":"2025-04-09","conditions":"Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8","enrollment":20},{"nctId":"NCT07358065","phase":"NA","title":"Clinical Application of Dynamic Multimodal Analgesia Regimen After Perianal Abscess Surgery","status":"NOT_YET_RECRUITING","sponsor":"The Affiliated Hospital of Putian University","startDate":"2026-01-01","conditions":"Clinical Application of Dynamic Multimodal Analgesia Regimen After Perianal Abscess Surgery","enrollment":135},{"nctId":"NCT02636569","phase":"PHASE2","title":"Topical Chemoprevention of Skin Cancer Biomarkers","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2017-10-25","conditions":"Non-melanoma Skin Cancer","enrollment":24},{"nctId":"NCT06379893","phase":"PHASE4","title":"A Real-World Evidence Study to Evaluate the Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis Pain","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-04-25","conditions":"Pain","enrollment":196},{"nctId":"NCT07328893","phase":"PHASE4","title":"Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy","status":"RECRUITING","sponsor":"Tata Main Hospital","startDate":"2025-12-27","conditions":"Analgesia; Postoperative","enrollment":106},{"nctId":"NCT03756961","phase":"NA","title":"Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery","status":"RECRUITING","sponsor":"Göteborg University","startDate":"2019-05-01","conditions":"Obesity, Pain, Postoperative","enrollment":220},{"nctId":"NCT06729073","phase":"PHASE1","title":"Comparison of Diclofenac Systemic Exposure From Two Different Products (AMZ001 and Diclofenac Diethylammonium 1.16% Gel) in Healthy Participants After Repeated Topical Administrations for 7 Days.","status":"COMPLETED","sponsor":"Amzell","startDate":"2024-11-29","conditions":"Healthy Volunteer","enrollment":34},{"nctId":"NCT07304882","phase":"PHASE3","title":"A Comparison of Recovery After Impacted Wisdom Tooth Removal","status":"COMPLETED","sponsor":"University of Science and Technology, Yemen","startDate":"2023-11-30","conditions":"Impacted Mandibular Third Molar Extraction, Post Operative Complications","enrollment":24},{"nctId":"NCT06685445","phase":"NA","title":"Continue ESPB & Continue ESPB Combined With SAPB for Thoracotomy","status":"COMPLETED","sponsor":"Bursa City Hospital","startDate":"2024-10-18","conditions":"Post-thoracotomy Pain","enrollment":60},{"nctId":"NCT06632184","phase":"PHASE4","title":"Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-12-01","conditions":"Postoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron","enrollment":40},{"nctId":"NCT07267182","phase":"NA","title":"Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief","status":"COMPLETED","sponsor":"Muhammad Aamir Latif","startDate":"2022-08-01","conditions":"Postoperative Pain","enrollment":240},{"nctId":"NCT07262463","phase":"NA","title":"Effect of Traction-Pressure-Release and Manual Pressure on Intramuscular Injection Pain","status":"COMPLETED","sponsor":"Melek Sahin","startDate":"2024-12-20","conditions":"Intramuscular Injection Pain","enrollment":174},{"nctId":"NCT07248332","phase":"PHASE1","title":"The Efface of Lidocaine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Liaquat National Hospital & Medical College","startDate":"2024-01-18","conditions":"Laparoscopic Cholecystectomy Surgery, Postoperative Pain Management","enrollment":168},{"nctId":"NCT07248384","phase":"PHASE1","title":"The Efface of Ketamine vs. Lidocaine in the Management of Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Liaquat National Hospital & Medical College","startDate":"2023-07-15","conditions":"Pain, Postoperative","enrollment":76},{"nctId":"NCT07248358","phase":"PHASE1","title":"The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Liaquat National Hospital & Medical College","startDate":"2023-06-15","conditions":"Laparoscopic Cholecystectomy Surgery, Postoperative Pain Management","enrollment":78},{"nctId":"NCT07237620","phase":"NA","title":"The Effect of Different Intracanal Medicaments on Periapical Lesion Healing","status":"RECRUITING","sponsor":"Mustafa Kemal University","startDate":"2025-09-15","conditions":"Periapical Lesion Healing, Apical Periodontitis","enrollment":60},{"nctId":"NCT06298383","phase":"NA","title":"The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-06-15","conditions":"Symptomatic Irreversible Pulpitis","enrollment":120},{"nctId":"NCT07104370","phase":"NA","title":"Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws","status":"RECRUITING","sponsor":"Semmelweis University","startDate":"2025-09-29","conditions":"Edentulous Alveolar Ridge, Edentulous Alveolar Ridge Atrophy","enrollment":30},{"nctId":"NCT07060976","phase":"NA","title":"To Check Dermatological Safety of Test Products by 24 Hours Patch Testing","status":"COMPLETED","sponsor":"Novamed Laboratories Pvt. Ltd.","startDate":"2025-07-21","conditions":"Healthy Participants","enrollment":26},{"nctId":"NCT07177560","phase":"","title":"Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS)","status":"COMPLETED","sponsor":"Gazi University","startDate":"2023-07-30","conditions":"Colorectal Cancer, Gastric Cancer (GC), Capecitabine","enrollment":151},{"nctId":"NCT07178639","phase":"NA","title":"Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract Surgery","status":"RECRUITING","sponsor":"Nemocnice Kolín","startDate":"2025-08-01","conditions":"Macular Oedema, Cataract Surgery, NSAID (Non-Steroidal Anti-Inflammatory Drug)","enrollment":150},{"nctId":"NCT05752526","phase":"PHASE1","title":"A Study of Diclofenac Gel in Women With Primary Dysmenorrhea","status":"COMPLETED","sponsor":"Daré Bioscience, Inc.","startDate":"2023-05-19","conditions":"Dysmenorrhea Primary","enrollment":42},{"nctId":"NCT05877027","phase":"NA","title":"Exercise vs. Topical Diclofenac vs. PRP","status":"COMPLETED","sponsor":"Istanbul University - Cerrahpasa","startDate":"2024-03-20","conditions":"Gonarthrosis","enrollment":82},{"nctId":"NCT06632015","phase":"NA","title":"Effect of DCS on Post-Endodontic Pain","status":"COMPLETED","sponsor":"Mustafa Kemal University","startDate":"2024-01-22","conditions":"Post Endodontic Pain","enrollment":90},{"nctId":"NCT06439251","phase":"PHASE1, PHASE2","title":"Effects of Mulligan Technique With or Without Diclofenac Phonophoresis on Patellofemoral Pain Syndrome.","status":"COMPLETED","sponsor":"University of Lahore","startDate":"2023-10-18","conditions":"Patellofemoral Pain Syndrome","enrollment":68},{"nctId":"NCT07101016","phase":"NA","title":"Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling","status":"NOT_YET_RECRUITING","sponsor":"Mariam Hesham Mahmoud Abdelfattah Eissa","startDate":"2025-08-01","conditions":"Root End Resection, Periapical Lesion, Single Rooted Teeth","enrollment":44},{"nctId":"NCT07063160","phase":"NA","title":"Effect of Acupressure Therapy on Pain, Fear, and Post-Injection Satisfaction in Patients Undergoing IM Injection","status":"COMPLETED","sponsor":"Eastern Mediterranean University","startDate":"2024-11-15","conditions":"Injection Fear, Injection Site","enrollment":68},{"nctId":"NCT07043699","phase":"NA","title":"Effect of Phonophoresis Versus Iontophoresis in the Treatment of Perimenopausal Plantar Fasciitis","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-12-01","conditions":"Plantar Fasciitis","enrollment":42},{"nctId":"NCT07040709","phase":"NA","title":"Efficacy of Peripheral Nerve Blocks in Total Knee Arthroplasty","status":"RECRUITING","sponsor":"Tokat Gaziosmanpasa University","startDate":"2025-06-08","conditions":"Postoperative Pain Following Knee Arthroplasty","enrollment":86},{"nctId":"NCT06918340","phase":"PHASE4","title":"Evaluation of Analgesic Efficacy of Lidocaine and Diclofenac Spray in Radial Artery Blood Gas Sampling by Visual Analogue Scale and Perfusion Index","status":"ACTIVE_NOT_RECRUITING","sponsor":"Haydarpasa Numune Training and Research Hospital","startDate":"2024-11-01","conditions":"Blood Gas Analysis, Topical Analgesia","enrollment":150},{"nctId":"NCT02193620","phase":"PHASE2, PHASE3","title":"Study of PHN131 in Patients After Surgery","status":"COMPLETED","sponsor":"PhytoHealth Corporation","startDate":"2013-04-30","conditions":"Analgesia Disorder","enrollment":106},{"nctId":"NCT06207253","phase":"PHASE2, PHASE3","title":"The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament","status":"RECRUITING","sponsor":"British University In Egypt","startDate":"2025-11","conditions":"Endodontic Disease, Pulp Disease, Dental, Intracanal Medication","enrollment":48},{"nctId":"NCT05882812","phase":"PHASE2","title":"Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis","status":"COMPLETED","sponsor":"ZetrOZ, Inc.","startDate":"2023-06-03","conditions":"Osteo Arthritis Knee, Arthritis","enrollment":200},{"nctId":"NCT06967363","phase":"","title":"Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-05-15","conditions":"Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain","enrollment":360},{"nctId":"NCT05050448","phase":"PHASE1, PHASE2","title":"Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain","status":"COMPLETED","sponsor":"ZetrOZ, Inc.","startDate":"2021-08-01","conditions":"Knee Osteoarthritis","enrollment":60},{"nctId":"NCT06954181","phase":"NA","title":"Quantification of Diclofenac 2.32% (Voltaren) in Rinse Water After Different Application Methods","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-03-26","conditions":"Healthy Participants","enrollment":33},{"nctId":"NCT06637111","phase":"NA","title":"Ultrasound Guidance of Office Hysteroscopy in Patients With History of Failure of Office Hysteroscopy Due to Cervical Stenosis.","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-10-30","conditions":"Hysteroscopy","enrollment":58},{"nctId":"NCT06158620","phase":"PHASE1, PHASE2","title":"Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2025-03-01","conditions":"Post Operative Pain, Urolithiasis, Ureter Calculi","enrollment":80},{"nctId":"NCT05968482","phase":"PHASE1","title":"Bioavailability and Safety Study Comparing Two Dose Levels of AMZ001 and One Dose Level of Diclofenac Sodium 1% Gel in Healthy Participants","status":"COMPLETED","sponsor":"Amzell","startDate":"2023-07-11","conditions":"Healthy","enrollment":74},{"nctId":"NCT06911437","phase":"","title":"Clinical Study on the Combination of Xiaoyu Zhitong Formula and Lymphatic Drainage Technique to Improve the Symptoms of Knee Pain and Swelling in Cold Dampness Obstruction Type","status":"ENROLLING_BY_INVITATION","sponsor":"tang jie","startDate":"2024-10-10","conditions":"Knee Osteoarthritis (OA)","enrollment":100},{"nctId":"NCT06795594","phase":"NA","title":"Effectiveness of Cheek Acupuncture Therapy for Pain Control After Cesarean Delivery","status":"COMPLETED","sponsor":"Beijing Tongren Hospital","startDate":"2025-01-05","conditions":"Acupuncture Analgesia","enrollment":80},{"nctId":"NCT06574191","phase":"NA","title":"The Effects of Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2025-01-29","conditions":"Knee Osteoarthritis","enrollment":220},{"nctId":"NCT06857110","phase":"NA","title":"\"Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures\"","status":"RECRUITING","sponsor":"Hospital Universitario San Ignacio","startDate":"2024-06-01","conditions":"Distal Radius Fracture","enrollment":50},{"nctId":"NCT06864078","phase":"NA","title":"IUCD Insertion in Patients Delivered by Cesarean Section","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-09-10","conditions":"IUD","enrollment":128},{"nctId":"NCT06510062","phase":"PHASE1","title":"Comparative Evaluation of Sustained Acoustic Medicine Device on Circulation","status":"COMPLETED","sponsor":"ZetrOZ, Inc.","startDate":"2024-07-22","conditions":"Measurement of Circulation on Anatomical Locations of the Body","enrollment":67},{"nctId":"NCT06257537","phase":"PHASE2","title":"Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis","status":"RECRUITING","sponsor":"ZetrOZ, Inc.","startDate":"2024-10-01","conditions":"Osteo Arthritis Knee, Arthritis","enrollment":300},{"nctId":"NCT05883241","phase":"PHASE1","title":"Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture","status":"RECRUITING","sponsor":"ZetrOZ, Inc.","startDate":"2023-06-01","conditions":"Bone Fracture, Fresh Fracture","enrollment":90},{"nctId":"NCT05254574","phase":"PHASE1","title":"Sustained Acoustic Medicine for Osteoarthritis Pain","status":"RECRUITING","sponsor":"ZetrOZ, Inc.","startDate":"2022-02-14","conditions":"Osteoarthritis","enrollment":200},{"nctId":"NCT02406014","phase":"PHASE4","title":"Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-04","conditions":"Actinic Keratosis (AK)","enrollment":502},{"nctId":"NCT06824025","phase":"EARLY_PHASE1","title":"Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial.","status":"NOT_YET_RECRUITING","sponsor":"Minia University","startDate":"2025-02-20","conditions":"Post-Dural Puncture Headache","enrollment":111},{"nctId":"NCT05387525","phase":"PHASE4","title":"A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp","status":"ACTIVE_NOT_RECRUITING","sponsor":"Almirall, S.A.","startDate":"2022-10-24","conditions":"Keratosis, Actinic","enrollment":447},{"nctId":"NCT05312645","phase":"PHASE3","title":"Diclofenac Gel in the Treatment of Cervicogenic Headache","status":"WITHDRAWN","sponsor":"Loma Linda University","startDate":"2023-12","conditions":"Cervicogenic Headache","enrollment":""},{"nctId":"NCT05026320","phase":"PHASE2","title":"A Clinical Trial to Compare Safety and Effectiveness for Relieving Tenderness of 10% Naproxen Gel vs. a 2.32% Diclofenac Diethylamine Gel in the Treatment of Strains and Bruises of the Legs.","status":"COMPLETED","sponsor":"Bayer","startDate":"2021-08-08","conditions":"Soft Tissue Injury","enrollment":76},{"nctId":"NCT06059339","phase":"NA","title":"Comparing Pericapsular Nerve Group Block with Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery","status":"COMPLETED","sponsor":"Marmara University","startDate":"2023-04-22","conditions":"Postoperative Pain, Total Hip Arthroplasty","enrollment":66},{"nctId":"NCT06602167","phase":"NA","title":"Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome","status":"RECRUITING","sponsor":"Affiliated Hospital of Qinghai University","startDate":"2024-10-08","conditions":"Capecitabine, Hand-foot Syndrome, Electroacupuncture","enrollment":220},{"nctId":"NCT05816226","phase":"PHASE3","title":"Topical Treatment for TMJ Arthralgia","status":"RECRUITING","sponsor":"University of the Pacific","startDate":"2023-06-01","conditions":"TMJ Pain","enrollment":90},{"nctId":"NCT06710600","phase":"NA","title":"Phototoxicity of Frequently Prescribed Medicines","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2022-09-22","conditions":"Phototoxicity","enrollment":12},{"nctId":"NCT06533397","phase":"NA","title":"The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation","status":"RECRUITING","sponsor":"Semmelweis University","startDate":"2024-08-24","conditions":"Alveolar Bone Loss, Edentulism Nos","enrollment":40},{"nctId":"NCT06053411","phase":"EARLY_PHASE1","title":"Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac","status":"RECRUITING","sponsor":"Washington State University","startDate":"2024-03-01","conditions":"Interaction","enrollment":30},{"nctId":"NCT06675734","phase":"","title":"Pain Management After Free Gingival Graft Surgery","status":"COMPLETED","sponsor":"Istanbul Aydın University","startDate":"2023-11-29","conditions":"Gingival Recession, Localized, Gingival Recession, Generalized, Gingival Recession, Mucogingival Surgery","enrollment":30},{"nctId":"NCT04611529","phase":"PHASE4","title":"Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2021-03-02","conditions":"Low Back Pain","enrollment":198},{"nctId":"NCT06630520","phase":"NA","title":"Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2022-03-20","conditions":"Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction","enrollment":288},{"nctId":"NCT06623929","phase":"","title":"Topical Treatments for Ankle Sprains","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-01-01","conditions":"Ankle Sprain","enrollment":100},{"nctId":"NCT06607861","phase":"EARLY_PHASE1","title":"Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Minia University","startDate":"2024-10-01","conditions":"Pain Score (VAS)","enrollment":114},{"nctId":"NCT06561035","phase":"PHASE3","title":"ACL-R Opioid Sparing Study","status":"ENROLLING_BY_INVITATION","sponsor":"Campbell Clinic","startDate":"2024-09-01","conditions":"Anterior Cruciate Ligament Injuries","enrollment":56},{"nctId":"NCT00140972","phase":"PHASE4","title":"A Study to Assess Etoricoxib Versus Diclofenac in Chinese Patients With Osteoarthritis of the Knee or Hip (0663-080)(COMPLETED)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2004-12-03","conditions":"Osteoarthritis","enrollment":160},{"nctId":"NCT00092703","phase":"PHASE3","title":"Investigational Drug Versus an Approved Drug in Patients With Osteoarthritis (0663-061)(COMPLETED)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-06-27","conditions":"Osteoarthritis","enrollment":6000},{"nctId":"NCT00542087","phase":"PHASE3","title":"Etoricoxib vs. Diclofenac in OA (0663-805)(COMPLETED)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-03-22","conditions":"Osteoarthritis","enrollment":516},{"nctId":"NCT06500871","phase":"EARLY_PHASE1","title":"Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-08","conditions":"Teeth With Acute Irreverseble Pulpitis","enrollment":40},{"nctId":"NCT04050644","phase":"PHASE4","title":"Comparison of Treatment With Preservative-free Dexamethasone 0.1% (Monofree Dexamethason) and Diclofenac 0.1% (Dicloabak) Eye Drops Versus Preserved Dexamethasone 0.1% (Maxidex) and Diclofenac 0.1% (Voltaren Ophtha) Eye Drops After Cataract Surgery","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2018-10-30","conditions":"Age-related Cataract","enrollment":100},{"nctId":"NCT06386926","phase":"NA","title":"Radial Shockwave Versus Ultrasound Phonophoresis","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-05-01","conditions":"Supraspinatus Tendinitis","enrollment":69},{"nctId":"NCT06192420","phase":"PHASE3","title":"TRAUMED - a Clinical Trial in Acute Ankle Sprain","status":"COMPLETED","sponsor":"Biologische Heilmittel Heel GmbH","startDate":"2018-02-26","conditions":"Ankle Sprain","enrollment":809},{"nctId":"NCT04438369","phase":"NA","title":"Evaluation of Ultrasound-guided Erector Spinae Block for Postoperative Analgesia in Laprascopic Ventral Hernia Repair.","status":"COMPLETED","sponsor":"Ostfold Hospital Trust","startDate":"2020-09-01","conditions":"Ventral Hernia, Postoperative Pain, Regional Anesthesia","enrollment":70},{"nctId":"NCT06231043","phase":"PHASE4","title":"Diclofenac IM Versus Tramadol IV in Acute Renal Colic, RCT","status":"COMPLETED","sponsor":"Lampang Hospital","startDate":"2022-04-27","conditions":"Acute Renal Colic","enrollment":68},{"nctId":"NCT06220279","phase":"NA","title":"Efficacy of Single Dose Rectal Diclofenac With Oral Diclofenac for the Relief of Perineal Pain Within 24 Hours After Episiotomy","status":"COMPLETED","sponsor":"Federal Teaching Hospital Abakaliki","startDate":"2021-06-01","conditions":"Pain Relief After Episiotomy","enrollment":146},{"nctId":"NCT05641246","phase":"PHASE2","title":"Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine","status":"COMPLETED","sponsor":"German University in Cairo","startDate":"2022-12-08","conditions":"Hand and Foot Syndrome","enrollment":86},{"nctId":"NCT06184685","phase":"PHASE2","title":"Safety and Efficacy of Sahasthara ME vs Diclofenac ME for Treating Primary Knee Osteoarthritis","status":"COMPLETED","sponsor":"Thammasat University","startDate":"2021-10-20","conditions":"Primary Knee Osteoarthritis","enrollment":87},{"nctId":"NCT05082662","phase":"PHASE1, PHASE2","title":"Bioequivalence Study to Compare Diclofenac Potassium Coated Tablet Versus Cataflam® 50 Coated Tablet","status":"COMPLETED","sponsor":"Humanis Saglık Anonim Sirketi","startDate":"2020-08-25","conditions":"Non-steroidal Anti-inflammatory (NSAID), Analgesic, Antipyretic","enrollment":36},{"nctId":"NCT05004519","phase":"NA","title":"Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass","status":"COMPLETED","sponsor":"matthieu clanet","startDate":"2021-10-05","conditions":"Analgesics, Opioid","enrollment":183},{"nctId":"NCT02183129","phase":"PHASE4","title":"Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"1999-04-01","conditions":"Osteoarthritis","enrollment":91},{"nctId":"NCT06105827","phase":"PHASE4","title":"Clinical Study of Ningmitai Capsule on Promoting the Passage of Residual Fragments After Ureteroscopic Lithotripsy","status":"COMPLETED","sponsor":"Xintian Pharmaceutical","startDate":"2016-10-02","conditions":"Ureteral Calculi","enrollment":251},{"nctId":"NCT04585334","phase":"PHASE4","title":"Effectiveness of Tricortin 1000 in Patients Affected by Chronic Low Back Pain","status":"UNKNOWN","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2019-03-25","conditions":"Low Back Pain, Mechanical","enrollment":300},{"nctId":"NCT06094361","phase":"NA","title":"\"IONTOPHORESIS vs. PHONOPHORESIS\" for Treatment of Subacromial Impingement Syndrome","status":"COMPLETED","sponsor":"Emre Şenocak","startDate":"2015-06-01","conditions":"Subacromial Impingement Syndrome","enrollment":43},{"nctId":"NCT03949673","phase":"PHASE2","title":"Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip","status":"TERMINATED","sponsor":"Regeneron Pharmaceuticals","startDate":"2019-04-08","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip","enrollment":23},{"nctId":"NCT06061835","phase":"NA","title":"Non-contrast Magnetic Resonance Angiography in Deep Inferior Epigastric Perforator Flap Breast Reconstruction Planning","status":"UNKNOWN","sponsor":"I.M. Sechenov First Moscow State Medical University","startDate":"2023-05-06","conditions":"Breast Cancer, Postsurgical Acquired Absence of Organ","enrollment":135},{"nctId":"NCT05653401","phase":"PHASE2","title":"Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine.","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2022-11-20","conditions":"Renal Colic","enrollment":800},{"nctId":"NCT02689024","phase":"PHASE4","title":"Delirium in Elderly Patients With Trauma of the Hip","status":"TERMINATED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2016-05","conditions":"Hip Fractures, Anesthesia","enrollment":239},{"nctId":"NCT04508894","phase":"NA","title":"Ketamine Versus Dexmedetomidine in Supraclavicular Brachial Plexus Block","status":"COMPLETED","sponsor":"Minia University","startDate":"2019-04-21","conditions":"Supraclavicular Brachial Plexus Block","enrollment":75},{"nctId":"NCT05413096","phase":"EARLY_PHASE1","title":"Combination of Diclofenac Potassium and Propolis in the Therapy of Oral Aphthosis","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2021-06-01","conditions":"Oral Mucositis, ORAS, Oral Infection","enrollment":100},{"nctId":"NCT04391842","phase":"PHASE1","title":"Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis","status":"COMPLETED","sponsor":"ZetrOZ, Inc.","startDate":"2019-09-01","conditions":"Osteo Arthritis Knee, Arthritis","enrollment":34},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57},{"nctId":"NCT04933058","phase":"NA","title":"Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure","status":"COMPLETED","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2021-12-05","conditions":"Women Undergoing Oocyte Retrieval Procedures","enrollment":100},{"nctId":"NCT05786352","phase":"NA","title":"Outcomes of Enhanced Recovery After Cesarean (ERAC) Protocol","status":"UNKNOWN","sponsor":"Zeynep Kamil Maternity and Pediatric Research and Training Hospital","startDate":"2023-04-01","conditions":"Cesarean Section Complications, ERAS","enrollment":1200},{"nctId":"NCT03304379","phase":"PHASE3","title":"Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2017-10-26","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip","enrollment":1650},{"nctId":"NCT04622839","phase":"NA","title":"Post-Operative Pain Control Following Shoulder Surgery","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2020-12-01","conditions":"Shoulder Pain","enrollment":74}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":212,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diclofenac Heumann gel"],"phase":"marketed","status":"active","brandName":"Diclofenac 1%","genericName":"Diclofenac 1%","companyName":"Daré Bioscience, Inc.","companyId":"dar-bioscience-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Topical treatment of localized pain and inflammation associated with osteoarthritis, musculoskeletal injuries, and other localized inflammatory conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}