{"id":"dichloroacetate-dca","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral neuropathy"},{"rate":null,"effect":"Elevated liver enzymes"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL306823","moleculeType":"Small molecule","molecularWeight":"150.92"},"_fixedAt":"2026-03-30T13:33:20.087263","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DCA activates pyruvate dehydrogenase complex by inhibiting its inhibitory kinase, promoting the conversion of pyruvate to acetyl-CoA and increasing aerobic metabolism. This metabolic shift reduces lactate production and may enhance mitochondrial function, with potential anti-cancer effects by reducing the Warburg effect (cancer cells' reliance on glycolysis) and promoting apoptosis in tumor cells.","oneSentence":"Dichloroacetate inhibits pyruvate dehydrogenase kinase, shifting cellular metabolism from glycolysis toward oxidative phosphorylation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:47.847Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glioblastoma multiforme"},{"name":"Recurrent or progressive glioblastoma"}]},"_fixedFields":["pubmed(779)"],"trialDetails":[{"nctId":"NCT05120284","phase":"PHASE2","title":"Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2022-07-01","conditions":"Glioblastoma Multiforme","enrollment":40},{"nctId":"NCT05317455","phase":"EARLY_PHASE1","title":"Regulation of Brain Glucose Metabolism in Type 1 Diabetes","status":"RECRUITING","sponsor":"Yale University","startDate":"2025-05-13","conditions":"Diabetes Mellitus, Type 1, Hypoglycemia Unawareness","enrollment":16},{"nctId":"NCT06931262","phase":"","title":"Expanded Access Treatment Protocol With DCA for Patients With PDCD","status":"AVAILABLE","sponsor":"Saol Therapeutics Inc","startDate":"","conditions":"Pyruvate Dehydrogenase Complex Deficiency","enrollment":""},{"nctId":"NCT02616484","phase":"PHASE3","title":"Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:","status":"ACTIVE_NOT_RECRUITING","sponsor":"Saol Therapeutics Inc","startDate":"2020-07-14","conditions":"Pyruvate Dehydrogenase Complex Deficiency","enrollment":34},{"nctId":"NCT04046081","phase":"NA","title":"A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2019-11-19","conditions":"Endometriosis","enrollment":30},{"nctId":"NCT01163487","phase":"PHASE1","title":"Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers","status":"COMPLETED","sponsor":"Daniel T. 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Used for Glioblastoma multiforme, Recurrent or progressive glioblastoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}