{"id":"dichlorisone","rwe":[{"pmid":"15838928","year":"2005","title":"Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry.","finding":"","journal":"Rapid communications in mass spectrometry : RCM","studyType":"Clinical Study"},{"pmid":"9044851","year":"1997","title":"Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function.","finding":"","journal":"Cancer research","studyType":"Clinical Study"},{"pmid":"5232041","year":"1967","title":"Effects of new 9,11-dihalogenated corticosteroids in various types of alopecia. II. Pituitary-adrenal responsiveness in patients treated with 16 alpha-methyl-dichlorisone alcohol.","finding":"","journal":"Journal of the Mount Sinai Hospital, New York","studyType":"Clinical Study"},{"pmid":"14229556","year":"1964","title":"[DICHLORISONE ACETATE (VISODERM) IN LOCAL DERMATOLOGIC THERAPHY].","finding":"","journal":"Annales medicales de Nancy","studyType":"Clinical Study"},{"pmid":"14052165","year":"1963","title":"DICHLORISONE TREATMENT OF ALOPECIA.","finding":"","journal":"Medical times","studyType":"Clinical Study"}],"tags":[{"label":"dichlorisone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diloderm","offLabel":[],"synonyms":["dichlorisone","dichlorisone acetate","diloderm"],"timeline":[],"approvals":[],"brandName":"Diloderm","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dichlorisone","explanation":"Imagine your skin has a fire burning inside it, causing redness and swelling. Diloderm helps put out that fire by reducing the chemicals that cause inflammation, which can help calm down the skin and reduce symptoms of conditions like eczema or psoriasis.","oneSentence":"Diloderm works by reducing inflammation in the skin through its anti-inflammatory properties.","technicalDetail":"Dichlorisone is a corticosteroid that exerts its anti-inflammatory effects by inhibiting the synthesis of pro-inflammatory mediators, such as prostaglandins and leukotrienes, and by stabilizing lysosomal membranes to reduce the release of inflammatory enzymes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3139","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dichlorisone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:39:01.638898","biosimilars":[],"competitors":[],"genericName":"dichlorisone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"AMW2MRV3OT","CHEBI":"CHEBI:135670","INN_ID":"938","UMLSCUI":"C0544366","ChEMBL_ID":"CHEMBL1385514","KEGG_DRUG":"D07814","PUBCHEM_CID":"20054892","SNOMEDCT_US":"116597002","SECONDARY_CAS_RN":"7008-26-6","MESH_SUPPLEMENTAL_RECORD_UI":"C020282"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Dermatology"],"biosimilarFilings":[],"recentPublications":[{"date":"2005","pmid":"15838928","title":"Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry.","journal":"Rapid communications in mass spectrometry : RCM"},{"date":"1997 Feb 15","pmid":"9044851","title":"Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function.","journal":"Cancer research"},{"date":"1967 Mar-Apr","pmid":"5232041","title":"Effects of new 9,11-dihalogenated corticosteroids in various types of alopecia. II. Pituitary-adrenal responsiveness in patients treated with 16 alpha-methyl-dichlorisone alcohol.","journal":"Journal of the Mount Sinai Hospital, New York"},{"date":"1964 Aug-Sep","pmid":"14229556","title":"[DICHLORISONE ACETATE (VISODERM) IN LOCAL DERMATOLOGIC THERAPHY].","journal":"Annales medicales de Nancy"},{"date":"1963 Nov","pmid":"14052165","title":"DICHLORISONE TREATMENT OF ALOPECIA.","journal":"Medical times"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diloderm (dichlorisone) is a small molecule drug in the dichlorisone class. Its exact target and mechanism of action are unknown, but it is used to treat various skin conditions. The commercial status of Diloderm is unclear, and it may be patented or have generic manufacturers. Key safety considerations include potential skin irritation and allergic reactions. Further research is needed to fully understand the pharmacology of Diloderm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}