{"id":"dibutylphthalate","rwe":[{"pmid":"41873316","year":"2026","title":"Dry Ice in Decoverslipping Microscopic Slides: A Novel Approach.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"41440744","year":"2025","title":"The Pyruvate-Glyoxalate Pathway as a Toxicity Assessment Tool of Xenobiotics: Lessons from Prebiotic Chemistry.","finding":"","journal":"Journal of xenobiotics","studyType":"Clinical Study"},{"pmid":"41317586","year":"2026","title":"From soil to fork: Are mulch films releasing additives to the soil and contaminating our food?","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"40373569","year":"2025","title":"Microplastic ingestion and Phthalate ester levels as plastic tracers in the Mediterranean Velella velella: a candidate plastic indicator for the pelagic neustonic environment.","finding":"","journal":"Marine pollution bulletin","studyType":"Clinical Study"},{"pmid":"40253153","year":"2025","title":"Dynamics in microbial communities and flavor characteristics before and after the end-point of Zhenjiang aromatic vinegar fermentation revealed by macro-transcriptomics and metabolomics.","finding":"","journal":"Food research international (Ottawa, Ont.)","studyType":"Clinical Study"}],"tags":[{"label":"dibutylphthalate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Transient receptor potential cation channel subfamily A member 1","category":"target"},{"label":"TRPA1","category":"gene"},{"label":"P03BX03","category":"atc"},{"label":"Active","category":"status"},{"label":"Plasticizers","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"butyl phthalate","offLabel":[],"synonyms":["dibutylphthalate","dibutyl phthalate","butyl phthalate","phthalate dibutyl"],"timeline":[],"approvals":[],"brandName":"Butyl Phthalate","ecosystem":[],"mechanism":{"target":"Transient receptor potential cation channel subfamily A member 1","targets":[{"gene":"TRPA1","source":"DrugCentral","target":"Transient receptor potential cation channel subfamily A member 1","protein":"Transient receptor potential cation channel subfamily A member 1"}],"modality":"Small Molecule","drugClass":"dibutylphthalate","explanation":"Imagine your body has special channels that help control how certain cells respond to stimuli. Butyl Phthalate is thought to affect these channels, potentially altering how cells behave. However, the exact details of this interaction are not well understood.","oneSentence":"Butyl Phthalate works by interacting with the transient receptor potential cation channel subfamily A member 1.","technicalDetail":"Butyl Phthalate is believed to modulate the activity of TRPA1 channels, which are involved in the detection of various stimuli, including pain, temperature, and chemical irritants."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4414","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=dibutylphthalate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dibutylphthalate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:38:56.328707","biosimilars":[],"competitors":[{"drugName":"diethyltoluamide","drugSlug":"diethyltoluamide","fdaApproval":"","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"dibutylphthalate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diethyltoluamide","brandName":"diethyltoluamide","genericName":"diethyltoluamide","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02688478","phase":"NA","title":"The Phthalate-Allergen Immune Response Study","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2017-02-02","conditions":["Allergies"],"enrollment":20,"completionDate":"2021-05-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000166643","MMSL":"NOCODE","NDDF":"006320","UNII":"2286E5R2KE","CHEBI":"CHEBI:34687","RXNORM":"1362873","UMLSCUI":"C0012052","ChEMBL_ID":"CHEMBL272485","DRUGBANK_ID":"DB13716","PDB_CHEM_ID":" DB7","PUBCHEM_CID":"3026","SNOMEDCT_US":"411442007","IUPHAR_LIGAND_ID":"6295","MESH_DESCRIPTOR_UI":"D003993"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":244,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"P03BX03","allCodes":["P03BX03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41873316","title":"Dry Ice in Decoverslipping Microscopic Slides: A Novel Approach.","journal":"Cureus"},{"date":"2025 Dec 1","pmid":"41440744","title":"The Pyruvate-Glyoxalate Pathway as a Toxicity Assessment Tool of Xenobiotics: Lessons from Prebiotic Chemistry.","journal":"Journal of xenobiotics"},{"date":"2026 Jan 15","pmid":"41317586","title":"From soil to fork: Are mulch films releasing additives to the soil and contaminating our food?","journal":"Food chemistry"},{"date":"2025 Aug","pmid":"40373569","title":"Microplastic ingestion and Phthalate ester levels as plastic tracers in the Mediterranean Velella velella: a candidate plastic indicator for the pelagic neustonic environment.","journal":"Marine pollution bulletin"},{"date":"2025 May","pmid":"40253153","title":"Dynamics in microbial communities and flavor characteristics before and after the end-point of Zhenjiang aromatic vinegar fermentation revealed by macro-transcriptomics and metabolomics.","journal":"Food research international (Ottawa, Ont.)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Butyl Phthalate, also known as dibutylphthalate, is a small molecule that targets the transient receptor potential cation channel subfamily A member 1. However, due to the lack of available information, its exact mechanism of action, pharmacokinetics, and commercial status are unknown. As a result, it is not possible to provide a comprehensive summary of its use, safety considerations, or approved indications. Further research is needed to determine the potential therapeutic applications and risks associated with dibutylphthalate. It is essential to consult reliable sources for accurate information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}