{"id":"dibunate","rwe":[{"pmid":"5338382","year":"1967","title":"Antitussive effect of ethyl dibunate in patients with chronic cough.","finding":"","journal":"Clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"6031473","year":"1967","title":"Pharmacology of ethyl dibunate, a new antitussive agent.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"5973161","year":"1966","title":"Metabolism of ethyl dibunate-14C: an antitussive drug.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"14081144","year":"1963","title":"ETHYL DIBUNATE: NEW NON-NARCOTIC FOR ACUTE COUGH.","finding":"","journal":"Pennsylvania medical journal (1928)","studyType":"Clinical Study"}],"tags":[{"label":"dibunate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DB16","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dibunafon","offLabel":[],"synonyms":["dibunate","sodium dibunate","dibunafon"],"timeline":[],"approvals":[],"brandName":"Dibunafon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"dibunate","explanation":"Imagine your body's cells have a factory inside them that produces chemicals. Dibunafon is like a brake pedal that slows down this factory, reducing the amount of chemicals produced. This can help treat certain conditions, but more research is needed to understand how it works and its potential effects on the body.","oneSentence":"Dibunafon works by inhibiting the activity of certain enzymes in the body.","technicalDetail":"Dibunafon is a competitive inhibitor of the enzyme responsible for the conversion of a certain substrate, thereby reducing the production of a specific metabolite."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/860","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dibunate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:38:51.589695","biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pentoxyverine","drugSlug":"pentoxyverine","fdaApproval":"","relationship":"same-class"},{"drugName":"clofedanol","drugSlug":"clofedanol","fdaApproval":"","relationship":"same-class"}],"genericName":"dibunate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzonatate","brandName":"benzonatate","genericName":"benzonatate","approvalYear":"1958","relationship":"same-class"},{"drugId":"pentoxyverine","brandName":"pentoxyverine","genericName":"pentoxyverine","approvalYear":"","relationship":"same-class"},{"drugId":"clofedanol","brandName":"clofedanol","genericName":"clofedanol","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004152","UNII":"ZXY319VL5S","CHEBI":"CHEBI:145567","INN_ID":"5285","RXNORM":"235860","UMLSCUI":"C1321984","ChEMBL_ID":"CHEMBL1865134","DRUGBANK_ID":"DB13796","PUBCHEM_CID":"84746","SNOMEDCT_US":"710945004","SECONDARY_CAS_RN":"14992-58-6"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DB16","allCodes":["R05DB16"]},"biosimilarFilings":[],"recentPublications":[{"date":"1967 May-Jun","pmid":"5338382","title":"Antitussive effect of ethyl dibunate in patients with chronic cough.","journal":"Clinical pharmacology and therapeutics"},{"date":"1967 Feb","pmid":"6031473","title":"Pharmacology of ethyl dibunate, a new antitussive agent.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1966 Aug","pmid":"5973161","title":"Metabolism of ethyl dibunate-14C: an antitussive drug.","journal":"Biochemical pharmacology"},{"date":"1963 Nov","pmid":"14081144","title":"ETHYL DIBUNATE: NEW NON-NARCOTIC FOR ACUTE COUGH.","journal":"Pennsylvania medical journal (1928)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dibunafon, also known as Dibunate Sodium, is a small molecule cough suppressant. It has been marketed under various names, including Becantyl, Becantex, and Linctussal, typically in dosages of 20 to 30 mg as a syrup or tablet.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}