{"id":"dibromotyrosine","rwe":[{"pmid":"38859975","year":"2024","title":"Diacron-Reactive Oxygen Metabolites Levels Are Initially Elevated in Patients with Bullous Pemphigoid.","finding":"","journal":"JID innovations : skin science from molecules to population health","studyType":"Clinical Study"},{"pmid":"38057869","year":"2023","title":"Design, synthesis, and characterization of novel system x(C)(-) transport inhibitors: inhibition of microglial glutamate release and neurotoxicity.","finding":"","journal":"Journal of neuroinflammation","studyType":"Clinical Study"},{"pmid":"37292591","year":"2023","title":"Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity.","finding":"","journal":"Research square","studyType":"Clinical Study"},{"pmid":"36463679","year":"2023","title":"Continuous cultivation of Dehalococcoides mccartyi with brominated tyrosine avoids toxic byproducts and gives tight reactor control.","finding":"","journal":"Water research","studyType":"Clinical Study"},{"pmid":"35877713","year":"2022","title":"Amino Acid-Coupled Bromophenols and a Sulfated Dimethylsulfonium Lanosol from the Red Alga Vertebrata lanosa.","finding":"","journal":"Marine drugs","studyType":"Clinical Study"}],"tags":[{"label":"dibromotyrosine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"H03BX02","category":"atc"},{"label":"Active","category":"status"},{"label":"Hyperthyroidism","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"biotiren","offLabel":[],"synonyms":["biotiren","bromotiren","dibromotyrosine","DL-3,5-Dibromotyrosine"],"timeline":[],"approvals":[],"brandName":"Biotiren","ecosystem":[{"indication":"Hyperthyroidism","otherDrugs":[{"name":"propylthiouracil","slug":"propylthiouracil","company":"Dava Pharms Inc"},{"name":"sodium iodide (131I)","slug":"sodium-iodide-(131i)","company":"Bracco"},{"name":"thiamazole","slug":"thiamazole","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"dibromotyrosine","explanation":"Think of it like a brake pedal for your thyroid gland. When you have hyperthyroidism, your thyroid gland is producing too many hormones, and Biotiren helps to slow down this process. This can help to bring your hormone levels back to a healthy balance.","oneSentence":"Biotiren works by inhibiting the production of thyroid hormones.","technicalDetail":"Biotiren exerts its effects by inhibiting the enzyme thyroid peroxidase, which is essential for the synthesis of thyroid hormones."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4413","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=dibromotyrosine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:38:46.870956","biosimilars":[],"competitors":[],"genericName":"dibromotyrosine","indications":{"approved":[{"name":"Hyperthyroidism","source":"DrugCentral","snomedId":34486009,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"QD49LEP46E","UMLSCUI":"C3652699","ChEMBL_ID":"CHEMBL1232132","DRUGBANK_ID":"DB07637","PDB_CHEM_ID":"DBY","PUBCHEM_CID":"67532"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":51,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"H03BX02","allCodes":["H03BX02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Jul","pmid":"38859975","title":"Diacron-Reactive Oxygen Metabolites Levels Are Initially Elevated in Patients with Bullous Pemphigoid.","journal":"JID innovations : skin science from molecules to population health"},{"date":"2023 Dec 6","pmid":"38057869","title":"Design, synthesis, and characterization of novel system x(C)(-) transport inhibitors: inhibition of microglial glutamate release and neurotoxicity.","journal":"Journal of neuroinflammation"},{"date":"2023 May 18","pmid":"37292591","title":"Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity.","journal":"Research square"},{"date":"2023 Feb 1","pmid":"36463679","title":"Continuous cultivation of Dehalococcoides mccartyi with brominated tyrosine avoids toxic byproducts and gives tight reactor control.","journal":"Water research"},{"date":"2022 Jun 27","pmid":"35877713","title":"Amino Acid-Coupled Bromophenols and a Sulfated Dimethylsulfonium Lanosol from the Red Alga Vertebrata lanosa.","journal":"Marine drugs"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Biotiren (dibromotyrosine) is a small molecule drug in the dibromotyrosine class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat hyperthyroidism, a condition characterized by an overproduction of thyroid hormones. The commercial status of Biotiren is unknown, and it is not clear if it is patented or available as a generic medication. Further information on its pharmacokinetics, safety, and efficacy is not available. As a result, its use should be approached with caution and under the guidance of a qualified healthcare professional.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}