{"id":"diazolidinylurea","rwe":[],"tags":[{"label":"Standardized Chemical Allergen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Liquid","category":"form"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"safetySignals":[{"llr":133.946,"date":"","count":38,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 38 times (LLR=134)"}],"commonSideEffects":[{"effect":"Drug abuse","drugRate":"LLR 134","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diazolidinyl urea","offLabel":[],"synonyms":["diazolidinyl urea","diazolidinylurea"],"timeline":[],"approvals":[],"brandName":"Diazolidinyl Urea","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Standardized Chemical Allergen","explanation":"Imagine your skin as a surface that can get infected by bacteria and mold. Diazolidinyl urea helps prevent this by slowly releasing formaldehyde, which kills these unwanted microorganisms. However, this process can also cause an allergic reaction in some people, leading to skin irritation and other symptoms.","oneSentence":"Diazolidinyl urea works by releasing formaldehyde, a known allergen and antimicrobial agent, to prevent the growth of bacteria and mold.","technicalDetail":"Diazolidinyl urea undergoes hydrolysis to release formaldehyde, which then acts as a biocide to inhibit the growth of microorganisms, including bacteria and mold."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4652","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=diazolidinylurea","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=diazolidinylurea","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:38:23.276830","biosimilars":[],"competitors":[],"genericName":"diazolidinylurea","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03611283","phase":"NA","title":"Topical Management of Xerostomia With Dry Mouth Products","status":"COMPLETED","sponsor":"Rosa María López-Pintor Muñoz","startDate":"2016-10-03","conditions":["Xerostomia","Sjogren's Syndrome"],"enrollment":28,"completionDate":"2017-11-30"},{"nctId":"NCT00876642","phase":"PHASE3","title":"Trial Comparing Best Supportive Care to Aloe Vera Gel","status":"COMPLETED","sponsor":"Marilia Medicine School","startDate":"2007-03","conditions":["Radiation Dermatitis"],"enrollment":137,"completionDate":"2008-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Liquid","formulations":[{"form":"LIQUID","route":"TOPICAL","productName":"Medi FectAntiseptic Hand Wash"},{"form":"LIQUID","route":"TOPICAL","productName":"SpectraGenix Hand SanitizerAntiseptic Hand Wash"}]},"crossReferences":{"NUI":"N0000179100","NDDF":"010058","UNII":"H5RIZ3MPW4","VUID":"4020117","CHEBI":"CHEBI:136014","VANDF":"4020117","RXNORM":"1310602","UMLSCUI":"C0057749","DRUGBANK_ID":"DB14173","PUBCHEM_CID":"62277","MESH_SUPPLEMENTAL_RECORD_UI":"C044982"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Diazolidinyl urea is a standardized chemical allergen classified as a small molecule. It is used as a preservative in personal care products, such as cosmetics and toothpaste, to prevent the growth of bacteria and mold. However, it has been identified as a potential allergen and is often used in patch tests to diagnose contact dermatitis. The commercial status of diazolidinyl urea is unclear, but it is likely available as a generic product. As a chemical allergen, diazolidinyl urea poses key safety considerations for individuals with sensitive skin or allergies.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}