{"id":"dianeal-extraneal-nutrineal","safety":{"commonSideEffects":[{"rate":null,"effect":"Peritonitis"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Electrolyte imbalances"},{"rate":null,"effect":"Protein loss"}]},"_chembl":{"chemblId":"CHEMBL1201472","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dianeal, Extraneal, and Nutrineal are sterile solutions used in peritoneal dialysis, a renal replacement therapy where dialysate is infused into the peritoneal cavity to allow diffusion and ultrafiltration of uremic toxins and excess fluid across the peritoneal membrane. Different formulations vary in glucose concentration, osmolarity, and nutrient content to optimize dialysis efficiency and patient tolerance. These solutions work passively through concentration gradients and osmotic pressure without requiring active molecular targeting.","oneSentence":"These are peritoneal dialysis solutions that facilitate fluid and solute exchange across the peritoneal membrane to remove waste products and excess water from the blood in patients with kidney failure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:21.228Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"End-stage renal disease requiring peritoneal dialysis"},{"name":"Chronic kidney disease Stage 5 managed via peritoneal dialysis"}]},"trialDetails":[{"nctId":"NCT01219959","phase":"PHASE3","title":"Dianeal, Extraneal, Nutrineal (D-E-N) Versus Dianeal Only in Diabetic Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients","status":"COMPLETED","sponsor":"Vantive Health LLC","startDate":"2010-10","conditions":"End Stage Renal Disease (ESRD), Diabetes, CAPD","enrollment":71},{"nctId":"NCT00567489","phase":"PHASE4","title":"IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients","status":"COMPLETED","sponsor":"Vantive Health LLC","startDate":"2008-01","conditions":"ESRD, Diabetes, CAPD","enrollment":137},{"nctId":"NCT00567398","phase":"PHASE3","title":"IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients","status":"COMPLETED","sponsor":"Vantive Health LLC","startDate":"2008-04","conditions":"ESRD, Diabetes","enrollment":43}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dianeal, Extraneal, Nutrineal","genericName":"Dianeal, Extraneal, Nutrineal","companyName":"Vantive Health LLC","companyId":"vantive-health-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These are peritoneal dialysis solutions that facilitate fluid and solute exchange across the peritoneal membrane to remove waste products and excess water from the blood in patients with kidney failure. Used for End-stage renal disease requiring peritoneal dialysis, Chronic kidney disease Stage 5 managed via peritoneal dialysis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}